Sleep deprivation elevates plasma corticosterone levels in neonatal rats

Ilana S. Hairston; Norman F. Ruby; Sheila Brooke; Christelle Peyron; Daniel P. Denning; H. Craig Heller; Robert M. Sapolsky

doi:10.1016/S0304-3940(01)02309-6

Sleep deprivation elevates plasma corticosterone levels in neonatal rats

Ilana S. Hairston, Norman F. Ruby, Sheila Brooke, Christelle Peyron, Daniel P. Denning, H. Craig Heller, Robert M. Sapolsky

Research output: Contribution to journal › Article › peer-review

Abstract

Plasma corticosterone (CORT) levels were measured after short periods of sleep deprivation in rats at postnatal days 12, 16, 20, and 24. There was an age-dependent increase in basal CORT levels and sleep deprivation significantly elevated CORT at all ages compared to non-sleep deprived controls. The levels of CORT after sleep deprivation in P16, P20 and P24 animals were similar, resulting in an age-dependent decrease of the magnitude of the response. Sleep deprived P12 animals had lower levels of CORT. However, the observed response to sleep deprivation suggests that sleep loss is a significant stressor at this age. These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	Neuroscience Letters
Volume	315
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3940(01)02309-6
State	Published - 23 Nov 2001
Externally published	Yes

Keywords

Corticosterone
Development
Neonatal rats
Sleep deprivation
Stress
Stress-hyporesponsive period

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/S0304-3940(01)02309-6

Cite this

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title = "Sleep deprivation elevates plasma corticosterone levels in neonatal rats",

abstract = "Plasma corticosterone (CORT) levels were measured after short periods of sleep deprivation in rats at postnatal days 12, 16, 20, and 24. There was an age-dependent increase in basal CORT levels and sleep deprivation significantly elevated CORT at all ages compared to non-sleep deprived controls. The levels of CORT after sleep deprivation in P16, P20 and P24 animals were similar, resulting in an age-dependent decrease of the magnitude of the response. Sleep deprived P12 animals had lower levels of CORT. However, the observed response to sleep deprivation suggests that sleep loss is a significant stressor at this age. These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones.",

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AU - Hairston, Ilana S.

AU - Ruby, Norman F.

AU - Brooke, Sheila

AU - Peyron, Christelle

AU - Denning, Daniel P.

AU - Heller, H. Craig

AU - Sapolsky, Robert M.

PY - 2001/11/23

Y1 - 2001/11/23

N2 - Plasma corticosterone (CORT) levels were measured after short periods of sleep deprivation in rats at postnatal days 12, 16, 20, and 24. There was an age-dependent increase in basal CORT levels and sleep deprivation significantly elevated CORT at all ages compared to non-sleep deprived controls. The levels of CORT after sleep deprivation in P16, P20 and P24 animals were similar, resulting in an age-dependent decrease of the magnitude of the response. Sleep deprived P12 animals had lower levels of CORT. However, the observed response to sleep deprivation suggests that sleep loss is a significant stressor at this age. These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones.

AB - Plasma corticosterone (CORT) levels were measured after short periods of sleep deprivation in rats at postnatal days 12, 16, 20, and 24. There was an age-dependent increase in basal CORT levels and sleep deprivation significantly elevated CORT at all ages compared to non-sleep deprived controls. The levels of CORT after sleep deprivation in P16, P20 and P24 animals were similar, resulting in an age-dependent decrease of the magnitude of the response. Sleep deprived P12 animals had lower levels of CORT. However, the observed response to sleep deprivation suggests that sleep loss is a significant stressor at this age. These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones.

KW - Corticosterone

KW - Development

KW - Neonatal rats

KW - Sleep deprivation

KW - Stress

KW - Stress-hyporesponsive period

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Sleep deprivation elevates plasma corticosterone levels in neonatal rats

Abstract

Keywords

ASJC Scopus subject areas

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