Sleep and Addictions: Linking Sleep Regulation With the Genesis of Addictive Behavior

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The main mystery about sleep is why we do not do more of it. This is even more enigmatic considering the overlap between sleep regulatory mechanisms and reward systems. Like the majority of psychiatric disorders, sleep disturbances are a central feature of addictions. In this chapter, a model is presented that demonstrates that key mechanisms involved in the susceptibility to engage in drug-seeking behaviors and to develop an addiction are linked to sleep and sleep disruption. The model proposes that the same systems that reinforce drug-seeking behaviors are also activated during sleep. As replay patterns during sleep are linked to memory consolidation, sleep may have a role in the creation of addiction. With this in mind, the proposed model may also provide a tentative answer to the questions posed above-suggesting that sleep deprivation, at least in a mild form, is reinforcing.

Original languageEnglish
Title of host publicationNeurological Modulation of Sleep
Subtitle of host publicationMechanisms and Function of Sleep Health
Number of pages11
ISBN (Print)9780128166581
StatePublished - 16 Jan 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.


  • Negative affect
  • Reward sensitivity
  • Synaptic plasticity

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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