Silica, silicosis, and lung cancer

Alon Peretz, Harvey Checkoway, Joel D. Kaufman, Israel Trajber, Yehuda Lerman

Research output: Contribution to journalReview articlepeer-review


Evidence that crystalline silica is associated with an increased rate of lung cancer led the International Agency for Research on Cancer to conclude in 1997 that crystalline silica is a known human carcinogen. In Israel too, crystalline silica is considered as such. The decision raised a debate in the scientific arena, and a few scientists have questioned the basis upon which causality was determined. We review the literature regarding the level of evidence of crystalline silica carcinogenicity.

Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalIsrael Medical Association Journal
Issue number2
StatePublished - Feb 2006
Externally publishedYes


  • Causality
  • IARC classification
  • Lung cancer
  • Silica
  • Silicosis

ASJC Scopus subject areas

  • General Medicine


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