Sex, mixability, and modularity

Adi Livnat; Christos Papadimitriou; Nicholas Pippenger; Marcus W. Feldman

doi:10.1073/pnas.0910734106

Sex, mixability, and modularity

Adi Livnat, Christos Papadimitriou, Nicholas Pippenger, Marcus W. Feldman

Research output: Contribution to journal › Article › peer-review

Abstract

The assumption that different genetic elements can make separate contributions to the same quantitative trait was originally made in order to reconcile biometry and Mendelism and ever since has been used in population genetics, specifically for the trait of fitness. Here we show that sex is responsible for the existence of separate genetic effects on fitness and, more generally, for the existence of a hierarchy of genetic evolutionary modules. Using the tools developed in the process, we also demonstrate that in terms of their fitness effects, separation and fusion of genes are associated with the increase and decrease of the recombination rate between them, respectively. Implications for sex and evolution theory are discussed.

Original language	English
Pages (from-to)	1452-1457
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	4
DOIs	https://doi.org/10.1073/pnas.0910734106
State	Published - 26 Jan 2010
Externally published	Yes

Keywords

Additive effects
Epistasis
Fitness
Genetic architecture
Recombination

ASJC Scopus subject areas

General

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10.1073/pnas.0910734106

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AU - Pippenger, Nicholas

AU - Feldman, Marcus W.

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AB - The assumption that different genetic elements can make separate contributions to the same quantitative trait was originally made in order to reconcile biometry and Mendelism and ever since has been used in population genetics, specifically for the trait of fitness. Here we show that sex is responsible for the existence of separate genetic effects on fitness and, more generally, for the existence of a hierarchy of genetic evolutionary modules. Using the tools developed in the process, we also demonstrate that in terms of their fitness effects, separation and fusion of genes are associated with the increase and decrease of the recombination rate between them, respectively. Implications for sex and evolution theory are discussed.

KW - Additive effects

KW - Epistasis

KW - Fitness

KW - Genetic architecture

KW - Recombination

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Sex, mixability, and modularity

Abstract

Keywords

ASJC Scopus subject areas

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