Sesquiterpene lactones from roots of Lactuca georgica

Klaudia Michalska, Alex Beharav, Wanda Kisiel

Research output: Contribution to journalArticlepeer-review


The wild lettuce Lactuca georgica Grossh. is a member of the section Lactuca of the genus Lactuca L. (Compositae). It belongs to the subsection Lactuca, along with Lactuca sativa L. and several other closely related species, and it is of interest for cultivated lettuce improvement. From roots of L. georgica 15 sesquiterpene lactone aglycones and glycosides were isolated, including 10 lactucin-type guaianolides. This is the first report on the co-occurrence in Lactuca species of seven lactucin derivatives esterified at C-8 with acetic, methacrylic and 4-hydroxyphenylacetic acids. Therefore, the esters can be regarded as characteristic for L. georgica. The new natural product lactucin-8-O-methacrylate and its 11β,13-dihydroderivative were characterized in detail following a comparative analysis of their 1D- and 2D-NMR and high resolution mass spectral data. Moreover, a case of mistaken identification of the former in a species of the family Bignoniaceae is discussed.

Original languageEnglish
Pages (from-to)10-12
Number of pages3
JournalPhytochemistry Letters
Issue number1
StatePublished - Dec 2014


  • Lactuca georgica
  • Lactucin esters
  • Methacrylates
  • Sesquiterpene lactones

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science


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