Sept4/ARTS is required for stem cell apoptosis and tumor suppression

María García-Fernández, Holger Kissel, Samara Brown, Travis Gorenc, Andrew J. Schile, Shahin Rafii, Sarit Larisch, Hermann Steller

Research output: Contribution to journalArticlepeer-review


Inhibitor of Apoptosis Proteins (IAPs) are frequently overexpressed in tumors and have become promising targets for developing anti-cancer drugs. IAPs can be inhibited by natural antagonists, but a physiological requirement of mammalian IAP antagonists remains to be established. Here we show that deletion of the mouse Sept4 gene, which encodes the IAP antagonist ARTS, promotes tumor development. Sept4-null mice have increased numbers of hematopoietic stem and progenitor cells, elevated XIAP protein, increased resistance to cell death, and accelerated tumor development in an Em-Myc background. These phenotypes are partially suppressed by inactivation of XIAP. Our results suggest that apoptosis plays an important role as a frontline defense against cancer by restricting the number of normal stem cells.

Original languageEnglish
Pages (from-to)2282-2293
Number of pages12
JournalGenes and Development
Issue number20
StatePublished - 15 Oct 2010


  • Apoptosis
  • Cancer
  • IAP
  • Lymphoma
  • Stem cells
  • Tumor suppressor

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


Dive into the research topics of 'Sept4/ARTS is required for stem cell apoptosis and tumor suppression'. Together they form a unique fingerprint.

Cite this