Sedentary behavior, physical inactivity, and metabolic syndrome: Pilot findings from the rapid assessment disuse index study

Kerem Shuval, Liora Sahar, Kelley Pettee Gabriel, Gregory Knell, Galit Weinstein, Tal Gafni Gal, Felipe Lobelo, Loretta DiPietro

Research output: Contribution to journalArticlepeer-review


Background: The Rapid Assessment Disuse Index (RADI) is a brief tool aimed to promptly assess primary care patients' overall physical inactivity and sedentary behavior. This study examines the relation between physical inactivity and sitting time (RADI) to cardiometabolic risk among primary care patients. Methods: Survey data and electronic medical record information were collated to explore the association between RADI scores (cumulative and sitting) to metabolic syndrome (and components) among women and men, using multivariable logistic regression. Results: Among women, the cumulative RADI score was not significantly associated with metabolic syndrome. However, the RADI sitting score was related to low high-density lipoprotein cholesterol and metabolic syndrome. That is, a transition to a higher RADI sitting score by 1 unit (vs remaining in the score) was related with a 1.4 and 1.3 times higher odds for having low high-density lipoprotein cholesterol (95% confidence interval, 1.05-1.87) and metabolic syndrome (95% confidence interval, 1.02-1.64), respectively. Among men, no significant relations were found. Conclusions: The RADI sitting score is positively and significantly related to high-density lipoprotein and metabolic syndrome among women, yet not men. Due to the RADI's potential clinical utility, future research should attempt to examine these relations in larger, more robust samples and adjudicated outcomes using a prospective design.

Original languageEnglish
Pages (from-to)1042-1046
Number of pages5
JournalJournal of Physical Activity and Health
Issue number10
StatePublished - 9 Sep 2020

Bibliographical note

Funding Information:
The present study did not receive financial support. The original RADI study was supported in part by grant UL1 RR024982 from the Clinical and Translational Science Award (CTSA) program of the National Center for Research Resources, National Institutes of Health. The authors have no competing interest to disclose. Ethical approval was provided by the Morehouse School of Medicine and the University of Haifa Institutional Review Boards.

Publisher Copyright:
© 2020 Human Kinetics, Inc.


  • Metabolic syndrome
  • Primary care
  • Public health
  • Sedentary behavior

ASJC Scopus subject areas

  • Medicine (all)


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