Secondary metabolites of aeromonas veronii strain A134 isolated from a Microcystis aeruginosa Bloom

Gad Weiss; Dimitry Kovalerchick; Omer Murik; Assaf Sukenik; Aaron Kaplan; Shmuel Carmeli

doi:10.3390/metabo9060110

Secondary metabolites of aeromonas veronii strain A134 isolated from a Microcystis aeruginosa Bloom

Gad Weiss, Dimitry Kovalerchick, Omer Murik, Assaf Sukenik, Aaron Kaplan, Shmuel Carmeli

Research output: Contribution to journal › Article › peer-review

Abstract

Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below.

Original language	English
Article number	110
Journal	Metabolites
Volume	9
Issue number	6
DOIs	https://doi.org/10.3390/metabo9060110
State	Published - Jun 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Aeromonas veronii
Microcystis aeruginosa
Secondary metabolites

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology

Access to Document

10.3390/metabo9060110

Cite this

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abstract = "Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below.",

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AU - Weiss, Gad

AU - Kovalerchick, Dimitry

AU - Murik, Omer

AU - Sukenik, Assaf

AU - Kaplan, Aaron

AU - Carmeli, Shmuel

PY - 2019/6

Y1 - 2019/6

N2 - Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below.

AB - Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below.

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Secondary metabolites of aeromonas veronii strain A134 isolated from a Microcystis aeruginosa Bloom

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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