Searching protein space for ancient sub-domain segments

Research output: Contribution to journalArticlepeer-review


Evolutionary processes that formed the current protein universe left their traces, among them homologous segments that recur, or are ‘reused,’ in multiple proteins. These reused segments, called ‘themes,’ can be found at various scales, the best known of which is the domain. Yet, recent studies have begun to focus on the evolutionary insights that can be derived from sub-domain-scale themes, which are candidates for traces of more ancient events. Characterizing these may provide clues to the emergence of domains. Particularly interesting are themes that are reused across dissimilar contexts, that is, where the rest of the protein domain differs. We survey computational studies identifying reused themes within different contexts at the sub-domain level.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalCurrent Opinion in Structural Biology
StatePublished - Jun 2021

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology


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