SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January-March 2021

Kamal Abu Jabal; Hila Ben-Amram; Karine Beiruti; Ira Brimat; Ashraf Abu Saada; Younes Bathish; Christian Sussan; Salman Zarka; Michael Edelstein

doi:10.1017/S0950268821001928

SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January-March 2021

Kamal Abu Jabal, Hila Ben-Amram, Karine Beiruti, Ira Brimat, Ashraf Abu Saada, Younes Bathish, Christian Sussan, Salman Zarka, Michael Edelstein

Research output: Contribution to journal › Article › peer-review

Abstract

Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second.

Original language	English
Article number	e239
Journal	Epidemiology and Infection
Volume	149
DOIs	https://doi.org/10.1017/S0950268821001928
State	Published - 17 Aug 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s). Published by Cambridge University Press.

Keywords

COVID-19
Israel
SARS-CoV-2
vaccine immunogenicity
vaccines

ASJC Scopus subject areas

Epidemiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1017/S0950268821001928

Cite this

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title = "SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January-March 2021",

abstract = "Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second.",

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language = "English",

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T1 - SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination

T2 - Israel, January-March 2021

AU - Abu Jabal, Kamal

AU - Ben-Amram, Hila

AU - Beiruti, Karine

AU - Brimat, Ira

AU - Abu Saada, Ashraf

AU - Bathish, Younes

AU - Sussan, Christian

AU - Zarka, Salman

AU - Edelstein, Michael

PY - 2021/8/17

Y1 - 2021/8/17

N2 - Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second.

AB - Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second.

KW - COVID-19

KW - Israel

KW - SARS-CoV-2

KW - vaccine immunogenicity

KW - vaccines

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DO - 10.1017/S0950268821001928

M3 - Article

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AN - SCOPUS:85113986690

SN - 0950-2688

VL - 149

JO - Epidemiology and Infection

JF - Epidemiology and Infection

M1 - e239

ER -

SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January-March 2021

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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