SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January-March 2021

Kamal Abu Jabal, Hila Ben-Amram, Karine Beiruti, Ira Brimat, Ashraf Abu Saada, Younes Bathish, Christian Sussan, Salman Zarka, Michael Edelstein

Research output: Contribution to journalArticlepeer-review

Abstract

Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second.

Original languageEnglish
Article numbere239
JournalEpidemiology and Infection
Volume149
DOIs
StatePublished - 17 Aug 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s). Published by Cambridge University Press.

Keywords

  • COVID-19
  • Israel
  • SARS-CoV-2
  • vaccine immunogenicity
  • vaccines

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

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