SARS-CoV-2 and seasonal influenza: similarities and disparities

Halima Dabaja-Younis, Eyal Fuchs, Nadeem Shorbaji, Tal Appel, Noah Carmon, Yael Shachor-Meyouhas, Manfred S. Green, Khetam Hussein

Research output: Contribution to journalArticlepeer-review


This report describes the differences in disease severity and clinical presentation between hospitalized patients with coronavirus disease 2019 (COVID-19) and others with seasonal influenza. A total of 136 influenza and 152 COVID-19 patients were included. Patients with influenza more frequently had dyspnea (p = 0.004), hypoxemia (p < 0.001), underlying diseases (p = 0.046), and elevated liver enzymes (p = 0.028). In contrast, patients with COVID-19 were overweight (p < 0.001), lymphopenic (p < 0.001), had elevated CRP (p = 0.011), and radiological abnormalities (p < 0.001). Patients with influenza were more severely ill on admission (NEWS > 5) (p < 0.001). However, length of hospital stay, ventilatory support, and 30-day-mortality were similar. Despite differences in clinical presentation and disease severity between influenza and COVID-19 patients, both groups had similar clinical outcomes.

Original languageEnglish
Pages (from-to)2761-2765
Number of pages5
JournalArchives of Virology
Issue number12
StatePublished - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

ASJC Scopus subject areas

  • Virology


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