SARS-CoV-2 and seasonal influenza: similarities and disparities

Halima Dabaja-Younis; Eyal Fuchs; Nadeem Shorbaji; Tal Appel; Noah Carmon; Yael Shachor-Meyouhas; Manfred S. Green; Khetam Hussein

doi:10.1007/s00705-022-05615-3

SARS-CoV-2 and seasonal influenza: similarities and disparities

Halima Dabaja-Younis, Eyal Fuchs, Nadeem Shorbaji, Tal Appel, Noah Carmon, Yael Shachor-Meyouhas, Manfred S. Green, Khetam Hussein

School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

This report describes the differences in disease severity and clinical presentation between hospitalized patients with coronavirus disease 2019 (COVID-19) and others with seasonal influenza. A total of 136 influenza and 152 COVID-19 patients were included. Patients with influenza more frequently had dyspnea (p = 0.004), hypoxemia (p < 0.001), underlying diseases (p = 0.046), and elevated liver enzymes (p = 0.028). In contrast, patients with COVID-19 were overweight (p < 0.001), lymphopenic (p < 0.001), had elevated CRP (p = 0.011), and radiological abnormalities (p < 0.001). Patients with influenza were more severely ill on admission (NEWS > 5) (p < 0.001). However, length of hospital stay, ventilatory support, and 30-day-mortality were similar. Despite differences in clinical presentation and disease severity between influenza and COVID-19 patients, both groups had similar clinical outcomes.

Original language	English
Pages (from-to)	2761-2765
Number of pages	5
Journal	Archives of Virology
Volume	167
Issue number	12
DOIs	https://doi.org/10.1007/s00705-022-05615-3
State	Published - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

ASJC Scopus subject areas

Virology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00705-022-05615-3

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title = "SARS-CoV-2 and seasonal influenza: similarities and disparities",

abstract = "This report describes the differences in disease severity and clinical presentation between hospitalized patients with coronavirus disease 2019 (COVID-19) and others with seasonal influenza. A total of 136 influenza and 152 COVID-19 patients were included. Patients with influenza more frequently had dyspnea (p = 0.004), hypoxemia (p < 0.001), underlying diseases (p = 0.046), and elevated liver enzymes (p = 0.028). In contrast, patients with COVID-19 were overweight (p < 0.001), lymphopenic (p < 0.001), had elevated CRP (p = 0.011), and radiological abnormalities (p < 0.001). Patients with influenza were more severely ill on admission (NEWS > 5) (p < 0.001). However, length of hospital stay, ventilatory support, and 30-day-mortality were similar. Despite differences in clinical presentation and disease severity between influenza and COVID-19 patients, both groups had similar clinical outcomes.",

author = "Halima Dabaja-Younis and Eyal Fuchs and Nadeem Shorbaji and Tal Appel and Noah Carmon and Yael Shachor-Meyouhas and Green, {Manfred S.} and Khetam Hussein",

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AU - Dabaja-Younis, Halima

AU - Fuchs, Eyal

AU - Shorbaji, Nadeem

AU - Appel, Tal

AU - Carmon, Noah

AU - Shachor-Meyouhas, Yael

AU - Green, Manfred S.

AU - Hussein, Khetam

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N2 - This report describes the differences in disease severity and clinical presentation between hospitalized patients with coronavirus disease 2019 (COVID-19) and others with seasonal influenza. A total of 136 influenza and 152 COVID-19 patients were included. Patients with influenza more frequently had dyspnea (p = 0.004), hypoxemia (p < 0.001), underlying diseases (p = 0.046), and elevated liver enzymes (p = 0.028). In contrast, patients with COVID-19 were overweight (p < 0.001), lymphopenic (p < 0.001), had elevated CRP (p = 0.011), and radiological abnormalities (p < 0.001). Patients with influenza were more severely ill on admission (NEWS > 5) (p < 0.001). However, length of hospital stay, ventilatory support, and 30-day-mortality were similar. Despite differences in clinical presentation and disease severity between influenza and COVID-19 patients, both groups had similar clinical outcomes.

AB - This report describes the differences in disease severity and clinical presentation between hospitalized patients with coronavirus disease 2019 (COVID-19) and others with seasonal influenza. A total of 136 influenza and 152 COVID-19 patients were included. Patients with influenza more frequently had dyspnea (p = 0.004), hypoxemia (p < 0.001), underlying diseases (p = 0.046), and elevated liver enzymes (p = 0.028). In contrast, patients with COVID-19 were overweight (p < 0.001), lymphopenic (p < 0.001), had elevated CRP (p = 0.011), and radiological abnormalities (p < 0.001). Patients with influenza were more severely ill on admission (NEWS > 5) (p < 0.001). However, length of hospital stay, ventilatory support, and 30-day-mortality were similar. Despite differences in clinical presentation and disease severity between influenza and COVID-19 patients, both groups had similar clinical outcomes.

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SARS-CoV-2 and seasonal influenza: similarities and disparities

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

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