Ripoptosome: A novel IAP-regulated cell death-signalling platform

Gergely Imre; Sarit Larisch; Krishnaraj Rajalingam

doi:10.1093/jmcb/mjr034

Ripoptosome: A novel IAP-regulated cell death-signalling platform

Gergely Imre, Sarit Larisch, Krishnaraj Rajalingam

Research output: Contribution to journal › Article › peer-review

Abstract

Recent studies have revealed that cell death stimuli can trigger programmed necrosis, necroptosis. Receptor-interacting serinethreonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis. Two studies now describe a novel RIP1 containing ∼2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation. Intriguingly, cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.

Original language	English
Pages (from-to)	324-326
Number of pages	3
Journal	Journal of Molecular Cell Biology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1093/jmcb/mjr034
State	Published - Dec 2011

ASJC Scopus subject areas

General Medicine

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title = "Ripoptosome: A novel IAP-regulated cell death-signalling platform",

abstract = "Recent studies have revealed that cell death stimuli can trigger programmed necrosis, necroptosis. Receptor-interacting serinethreonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis. Two studies now describe a novel RIP1 containing ∼2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation. Intriguingly, cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.",

author = "Gergely Imre and Sarit Larisch and Krishnaraj Rajalingam",

year = "2011",

month = dec,

doi = "10.1093/jmcb/mjr034",

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AU - Larisch, Sarit

AU - Rajalingam, Krishnaraj

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AB - Recent studies have revealed that cell death stimuli can trigger programmed necrosis, necroptosis. Receptor-interacting serinethreonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis. Two studies now describe a novel RIP1 containing ∼2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation. Intriguingly, cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.

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Ripoptosome: A novel IAP-regulated cell death-signalling platform

Abstract

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