Ripoptosome: A novel IAP-regulated cell death-signalling platform

Gergely Imre, Sarit Larisch, Krishnaraj Rajalingam

Research output: Contribution to journalArticlepeer-review


Recent studies have revealed that cell death stimuli can trigger programmed necrosis, necroptosis. Receptor-interacting serinethreonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis. Two studies now describe a novel RIP1 containing ∼2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation. Intriguingly, cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.

Original languageEnglish
Pages (from-to)324-326
Number of pages3
JournalJournal of Molecular Cell Biology
Issue number6
StatePublished - Dec 2011

ASJC Scopus subject areas

  • General Medicine


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