Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

Robert Melillo; Gerry Leisman; Calixto Machado; Yanin Machado-Ferrer; Mauricio Chinchilla-Acosta; Shanine Kamgang; Ty Melillo; Eli Carmeli

doi:10.3389/fneur.2022.922322

Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

Robert Melillo, Gerry Leisman, Calixto Machado, Yanin Machado-Ferrer, Mauricio Chinchilla-Acosta, Shanine Kamgang, Ty Melillo, Eli Carmeli

Department of Physical Therapy

Research output: Contribution to journal › Review article › peer-review

Abstract

We provide evidence to support the contention that many aspects of Autistic Spectrum Disorder (ASD) are related to interregional brain functional disconnectivity associated with maturational delays in the development of brain networks. We think a delay in brain maturation in some networks may result in an increase in cortical maturation and development in other networks, leading to a developmental asynchrony and an unevenness of functional skills and symptoms. The paper supports the close relationship between retained primitive reflexes and cognitive and motor function in general and in ASD in particular provided to indicate that the inhibition of RPRs can effect positive change in ASD.

Original language	English
Article number	922322
Journal	Frontiers in Neurology
Volume	13
DOIs	https://doi.org/10.3389/fneur.2022.922322
State	Published - 7 Jul 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Melillo, Leisman, Machado, Machado-Ferrer, Chinchilla-Acosta, Kamgang, Melillo and Carmeli.

Keywords

autism spectrum disorders
bottom-up processing
maturational delay
neuronal synchrony
retained primitive reflexes
top-down processing

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.3389/fneur.2022.922322

Cite this

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title = "Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders",

abstract = "We provide evidence to support the contention that many aspects of Autistic Spectrum Disorder (ASD) are related to interregional brain functional disconnectivity associated with maturational delays in the development of brain networks. We think a delay in brain maturation in some networks may result in an increase in cortical maturation and development in other networks, leading to a developmental asynchrony and an unevenness of functional skills and symptoms. The paper supports the close relationship between retained primitive reflexes and cognitive and motor function in general and in ASD in particular provided to indicate that the inhibition of RPRs can effect positive change in ASD.",

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AU - Melillo, Robert

AU - Leisman, Gerry

AU - Machado, Calixto

AU - Machado-Ferrer, Yanin

AU - Chinchilla-Acosta, Mauricio

AU - Kamgang, Shanine

AU - Melillo, Ty

AU - Carmeli, Eli

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AB - We provide evidence to support the contention that many aspects of Autistic Spectrum Disorder (ASD) are related to interregional brain functional disconnectivity associated with maturational delays in the development of brain networks. We think a delay in brain maturation in some networks may result in an increase in cortical maturation and development in other networks, leading to a developmental asynchrony and an unevenness of functional skills and symptoms. The paper supports the close relationship between retained primitive reflexes and cognitive and motor function in general and in ASD in particular provided to indicate that the inhibition of RPRs can effect positive change in ASD.

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KW - bottom-up processing

KW - maturational delay

KW - neuronal synchrony

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Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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