Restoration of serotonergic innervation underlies the behavioral effects of raphe grafts

Gal Richter-Levin, Menahem Segal

Research output: Contribution to journalArticlepeer-review

Abstract

It has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus10,23,24 and behaviors associated with serotonin14,18,20. To test the possibility that the behavioral effects of these grafts result from non-specific actions of the grafted tissue or the grafting procedure itself8,11, we compared raphe grafts with septal grafts, in serotonin-depleted rats. We also compared the effects of a serotonin synthesis inhibitor, p-chlorophenylalanine, on the behavior of normal, serotonin-depleted and raphe-grafted rats. The results indicate that the bulk of behavioral effects of raphe grafts are due to the serotonergic nature of the graft.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalBrain Research
Volume566
Issue number1-2
DOIs
StatePublished - 6 Dec 1991
Externally publishedYes

Keywords

  • Graft
  • Hippocampus
  • Raphe
  • Serotonin
  • Spatial memory

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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