Restoration of serotonergic innervation underlies the behavioral effects of raphe grafts

Gal Richter-Levin; Menahem Segal

doi:10.1016/0006-8993(91)91676-R

Restoration of serotonergic innervation underlies the behavioral effects of raphe grafts

Research output: Contribution to journal › Article › peer-review

Abstract

It has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus^10,23,24 and behaviors associated with serotonin^14,18,20. To test the possibility that the behavioral effects of these grafts result from non-specific actions of the grafted tissue or the grafting procedure itself^8,11, we compared raphe grafts with septal grafts, in serotonin-depleted rats. We also compared the effects of a serotonin synthesis inhibitor, p-chlorophenylalanine, on the behavior of normal, serotonin-depleted and raphe-grafted rats. The results indicate that the bulk of behavioral effects of raphe grafts are due to the serotonergic nature of the graft.

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	Brain Research
Volume	566
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91676-R
State	Published - 6 Dec 1991
Externally published	Yes

Keywords

Graft
Hippocampus
Raphe
Serotonin
Spatial memory

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)91676-R

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abstract = "It has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus10,23,24 and behaviors associated with serotonin14,18,20. To test the possibility that the behavioral effects of these grafts result from non-specific actions of the grafted tissue or the grafting procedure itself8,11, we compared raphe grafts with septal grafts, in serotonin-depleted rats. We also compared the effects of a serotonin synthesis inhibitor, p-chlorophenylalanine, on the behavior of normal, serotonin-depleted and raphe-grafted rats. The results indicate that the bulk of behavioral effects of raphe grafts are due to the serotonergic nature of the graft.",

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N2 - It has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus10,23,24 and behaviors associated with serotonin14,18,20. To test the possibility that the behavioral effects of these grafts result from non-specific actions of the grafted tissue or the grafting procedure itself8,11, we compared raphe grafts with septal grafts, in serotonin-depleted rats. We also compared the effects of a serotonin synthesis inhibitor, p-chlorophenylalanine, on the behavior of normal, serotonin-depleted and raphe-grafted rats. The results indicate that the bulk of behavioral effects of raphe grafts are due to the serotonergic nature of the graft.

AB - It has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus10,23,24 and behaviors associated with serotonin14,18,20. To test the possibility that the behavioral effects of these grafts result from non-specific actions of the grafted tissue or the grafting procedure itself8,11, we compared raphe grafts with septal grafts, in serotonin-depleted rats. We also compared the effects of a serotonin synthesis inhibitor, p-chlorophenylalanine, on the behavior of normal, serotonin-depleted and raphe-grafted rats. The results indicate that the bulk of behavioral effects of raphe grafts are due to the serotonergic nature of the graft.

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KW - Hippocampus

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Restoration of serotonergic innervation underlies the behavioral effects of raphe grafts

Abstract

Keywords

ASJC Scopus subject areas

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