Abstract
The physiological resolution of a well-orchestrated inflammatory response is essential to maintain homeostasis. Therefore, gaining a comprehensive understanding in molecular terms of the events that direct the termination of acute inflammation is imperative. Recently, new families of local-acting mediators were discovered that are biosynthesized from the essential fatty acids eicosapentaenoic acid and docosahexaenoic acid. These new chemical mediators are endogenously generated in inflammatory exudates collected during the resolution phase, and were termed resolvins and protectins because specific members of these families control the magnitude and duration of inflammation in animals. In addition, recent results indicate novel actions of resolvins and protectins in removing chemokines ferried from the tissue by apoptotic neutrophils and T cells during resolution. Here, we review recent advances on the biosynthesis and actions of these novel anti-inflammatory and proresolving mediators.
| Original language | English |
|---|---|
| Pages (from-to) | 176-183 |
| Number of pages | 8 |
| Journal | Trends in Immunology |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2007 |
Bibliographical note
Funding Information:Studies in C.N.S.'s laboratory were supported in part by NIH grants GM38675, DK074448 and P-50 DE-016191. A.A. was awarded the McDuffie Fellowship from the Arthritis Foundation during the course of the studies reviewed herein. We also thank Stacey Lindberg and Mary Halm Small for assistance in preparing this manuscript.
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology