Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks

Alexander Dvilansky; Shmuel Rishpon; Ilana Nathan; Zippora Zolotow; Amos D. Korczyn

doi:10.1016/0304-3959(76)90009-9

Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks

Alexander Dvilansky, Shmuel Rishpon, Ilana Nathan, Zippora Zolotow, Amos D. Korczyn

Research output: Contribution to journal › Article › peer-review

Abstract

Experiments were carried out in order to further delineate the pathophysiology of the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets from normal subjects were incubated with ¹⁴ C-labelled 5-HT, and the release of 5-HT was measured following exposure of these platelets to plasma taken from migraine patients during an attack or at headache-free intervals. Plasma taken during attacks released significantly more 5-HT. It is concluded that factor (s) exist in the serum during migraine attacks, which can cause 5-HT release from normal platelets. The identification of this factor may be important.

Original language	English
Pages (from-to)	315-318
Number of pages	4
Journal	Pain
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/0304-3959(76)90009-9
State	Published - Sep 1976
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology
Anesthesiology and Pain Medicine

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10.1016/0304-3959(76)90009-9

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title = "Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks",

abstract = "Experiments were carried out in order to further delineate the pathophysiology of the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets from normal subjects were incubated with 14 C-labelled 5-HT, and the release of 5-HT was measured following exposure of these platelets to plasma taken from migraine patients during an attack or at headache-free intervals. Plasma taken during attacks released significantly more 5-HT. It is concluded that factor (s) exist in the serum during migraine attacks, which can cause 5-HT release from normal platelets. The identification of this factor may be important.",

author = "Alexander Dvilansky and Shmuel Rishpon and Ilana Nathan and Zippora Zolotow and Korczyn, {Amos D.}",

year = "1976",

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AU - Dvilansky, Alexander

AU - Rishpon, Shmuel

AU - Nathan, Ilana

AU - Zolotow, Zippora

AU - Korczyn, Amos D.

PY - 1976/9

Y1 - 1976/9

N2 - Experiments were carried out in order to further delineate the pathophysiology of the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets from normal subjects were incubated with 14 C-labelled 5-HT, and the release of 5-HT was measured following exposure of these platelets to plasma taken from migraine patients during an attack or at headache-free intervals. Plasma taken during attacks released significantly more 5-HT. It is concluded that factor (s) exist in the serum during migraine attacks, which can cause 5-HT release from normal platelets. The identification of this factor may be important.

AB - Experiments were carried out in order to further delineate the pathophysiology of the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets from normal subjects were incubated with 14 C-labelled 5-HT, and the release of 5-HT was measured following exposure of these platelets to plasma taken from migraine patients during an attack or at headache-free intervals. Plasma taken during attacks released significantly more 5-HT. It is concluded that factor (s) exist in the serum during migraine attacks, which can cause 5-HT release from normal platelets. The identification of this factor may be important.

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JO - Pain

JF - Pain

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ER -

Release of platelet 5-hydroxytryptamine by plasma taken from patients during and between migraine attacks

Abstract

ASJC Scopus subject areas

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