Reduced rate of side effects associated with separate administration of MMR and DTaP-Hib-IPV vaccinations

Elena Shneyer, Avshalom Strulov, Yaakov Rosenfeld

Research output: Contribution to journalArticlepeer-review


Background: According to the Israeli immunization schedule, 1 year old babies should receive two concomitant vaccinations: MMR (measles-mumps-rubella), and DTap-Hib-IPV (diphtheria tetanus acellular pertussis-Haemophilus influenzae type b-poliomyelitis). However, about one-third of infants in Israel receive these vaccinations separately. Nurses at a primary care prevention clinic in Israel observed that the separate mode of vaccination is associated with a lower rate of side effects. Objectives: To validate this observation and determine whether it represents an exception or the rule. Methods: A nested prospective follow-up study was conducted in a primary care clinic in Israel. The survey included 191 mothers and their offspring born during 2004/2005. The mothers were interviewed over the telephone 2 weeks after the day of vaccination. Results: The rate of adverse effects in children who received the injections separately was significantly lower than among those who were vaccinated simultaneously (40% vs. 57%). Conclusions: It may be necessary to reconsider the current vaccination policy regarding concomitant injections.

Original languageEnglish
Pages (from-to)735-738
Number of pages4
JournalIsrael Medical Association Journal
Issue number12
StatePublished - Dec 2009


  • Adverse effects
  • DTap-Hib-IPV
  • Measles-mumps-rubella
  • Vaccinations

ASJC Scopus subject areas

  • General Medicine


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