Quorum sensing inhibitors from the sea discovered using bacterial N-acyl-homoserine lactone-based biosensors

Saurav Kumar, Valeria Costantino, Vittorio Venturi, Laura Steindler

Research output: Contribution to journalReview articlepeer-review

Abstract

Marine natural products with antibiotic activity have been a rich source of drug discovery; however, the emergence of antibiotic-resistant bacterial strains has turned attention towards the discovery of alternative innovative strategies to combat pathogens. In many pathogenic bacteria, the expression of virulence factors is under the regulation of quorum sensing (QS). QS inhibitors (QSIs) present a promising alternative or potential synergistic treatment since they disrupt the signaling pathway used for intra- and interspecies coordination of expression of virulence factors. This review covers the set of molecules showing QSI activity that were isolated from marine organisms, including plants (algae), animals (sponges, cnidarians, and bryozoans), and microorganisms (bacteria, fungi, and cyanobacteria). The compounds found and the methods used for their isolation are the emphasis of this review.

Original languageEnglish
Article number53
JournalMarine Drugs
Volume15
Issue number3
DOIs
StatePublished - Mar 2017

Bibliographical note

Funding Information:
This study was supported by the Bi-lateral Italy-Israel R&D grant, MOST grant#10705-3 to Laura Steindler and Vittorio Venturi entitled: "A novel approach to fight antibiotic-resistant pathogens: acquisition of quorum sensing inhibitors from marine sponges" (from the Ministry of Science and Technology, Israel). The work was partially supported by the European Union's Seventh Framework Program (FP7) 2007-2013 under Grant Agreement No. 311848 (Bluegenics). Kumar Saurav had a post-doctoral fellowship from the Israeli Council for Higher Education (VATAT) and the University of Haifa.

Publisher Copyright:
© 2017 by the authors.

Keywords

  • Antimicrobial resistance
  • Marine natural products
  • N-acyl homoserine lactones
  • Quorum quenching
  • Quorum-sensing inhibitors

ASJC Scopus subject areas

  • Drug Discovery

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