Abstract
Marine natural products with antibiotic activity have been a rich source of drug discovery; however, the emergence of antibiotic-resistant bacterial strains has turned attention towards the discovery of alternative innovative strategies to combat pathogens. In many pathogenic bacteria, the expression of virulence factors is under the regulation of quorum sensing (QS). QS inhibitors (QSIs) present a promising alternative or potential synergistic treatment since they disrupt the signaling pathway used for intra- and interspecies coordination of expression of virulence factors. This review covers the set of molecules showing QSI activity that were isolated from marine organisms, including plants (algae), animals (sponges, cnidarians, and bryozoans), and microorganisms (bacteria, fungi, and cyanobacteria). The compounds found and the methods used for their isolation are the emphasis of this review.
| Original language | English |
|---|---|
| Article number | 53 |
| Journal | Marine Drugs |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2017 |
Bibliographical note
Funding Information:This study was supported by the Bi-lateral Italy-Israel R&D grant, MOST grant#10705-3 to Laura Steindler and Vittorio Venturi entitled: "A novel approach to fight antibiotic-resistant pathogens: acquisition of quorum sensing inhibitors from marine sponges" (from the Ministry of Science and Technology, Israel). The work was partially supported by the European Union's Seventh Framework Program (FP7) 2007-2013 under Grant Agreement No. 311848 (Bluegenics). Kumar Saurav had a post-doctoral fellowship from the Israeli Council for Higher Education (VATAT) and the University of Haifa.
Publisher Copyright:
© 2017 by the authors.
Keywords
- Antimicrobial resistance
- Marine natural products
- N-acyl homoserine lactones
- Quorum quenching
- Quorum-sensing inhibitors
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Pharmaceutical Science