TY - JOUR
T1 - Quantitative Dynamic Allodynograph—A Standardized Measure for Testing Dynamic Mechanical Allodynia in Chronic Limb Pain
AU - Turgeman Dahan, Noy
AU - Vatine, Jean Jacques
AU - Weissman-Fogel, Irit
AU - Karpin, Hana
AU - Shmuely, Sharon
AU - Bar-Shalita, Tami
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/9
Y1 - 2023/9
N2 - BACKGROUND: Dynamic mechanical allodynia (DMA) is both a symptom and a central sensitization sign, yet no standardized method for quantifying the DMA area has been reported. This study aimed to establish psychometric properties for
Quantitative Dynamic Allodynography (
QDA), a newly developed protocol measuring the DMA area as a percentage of the body surface.
METHODS: Seventy-eight patients aged 18-65 diagnosed with chronic complex regional pain syndrome (CRPS) participated in this study. Test-retest reliability was conducted twice, one week apart (N = 20), and inter-rater (N = 3) reliability was conducted on 10 participants. Disease severity (
CRPS Severity Score,
CSS), pain intensity (VAS), and quality of life (SF-36) measures were utilized to test construct validity.
RESULTS: High inter-rater reliability (intraclass correlation coefficient (ICC) = 0.96,
p < 0.001) and test-retest reliability (
r = 0.98,
p < 0.001) were found. Furthermore, the QDA score was found to be correlated with the CSS (
r = 0.47,
p < 0.001), VAS (
r = 0.37,
p < 0.001), and the SF-36 physical health total (
r = -0.47,
p < 0.001) scores.
CONCLUSION: The QDA is the first developed reliable and valid protocol for measuring DMA in a clinical setting and may be used as a diagnostic and prognostic measure in clinics and in research, advancing the pain precision medicine approach.
AB - BACKGROUND: Dynamic mechanical allodynia (DMA) is both a symptom and a central sensitization sign, yet no standardized method for quantifying the DMA area has been reported. This study aimed to establish psychometric properties for
Quantitative Dynamic Allodynography (
QDA), a newly developed protocol measuring the DMA area as a percentage of the body surface.
METHODS: Seventy-eight patients aged 18-65 diagnosed with chronic complex regional pain syndrome (CRPS) participated in this study. Test-retest reliability was conducted twice, one week apart (N = 20), and inter-rater (N = 3) reliability was conducted on 10 participants. Disease severity (
CRPS Severity Score,
CSS), pain intensity (VAS), and quality of life (SF-36) measures were utilized to test construct validity.
RESULTS: High inter-rater reliability (intraclass correlation coefficient (ICC) = 0.96,
p < 0.001) and test-retest reliability (
r = 0.98,
p < 0.001) were found. Furthermore, the QDA score was found to be correlated with the CSS (
r = 0.47,
p < 0.001), VAS (
r = 0.37,
p < 0.001), and the SF-36 physical health total (
r = -0.47,
p < 0.001) scores.
CONCLUSION: The QDA is the first developed reliable and valid protocol for measuring DMA in a clinical setting and may be used as a diagnostic and prognostic measure in clinics and in research, advancing the pain precision medicine approach.
KW - Chronic Pain/diagnosis
KW - Complex Regional Pain Syndromes
KW - Humans
KW - Hyperalgesia/diagnosis
KW - Quality of Life
KW - Reproducibility of Results
UR - http://www.scopus.com/inward/record.url?scp=85172734517&partnerID=8YFLogxK
U2 - 10.3390/s23187949
DO - 10.3390/s23187949
M3 - Article
C2 - 37766006
AN - SCOPUS:85172734517
SN - 1424-8220
VL - 23
JO - Sensors
JF - Sensors
IS - 18
M1 - 7949
ER -