Quality of Life of Mothers of Infants Subjected to Neonatal Cardiac Surgery: The Importance of Psychosocial Factors

Amy Jo Lisanti, Nadya Golfenshtein, Bradley S. Marino, Liming Huang, Alexandra L. Hanlon, Alicia J. Lozano, Martha A.Q. Curley, Barbara Medoff-Cooper

Research output: Contribution to journalArticlepeer-review


Background: The World Health Organization acknowledges quality of life (QOL) as subjectively perceived overall well-being by the individual and recognizes it as an essential construct for overall health and wellness. The purpose of this study was to examine the association of infant, environmental, and parental factors with the QOL of mothers of infants at four months post-hospital discharge from cardiac surgery. Methods: Secondary analysis of prospectively collected data from the REACH randomized clinical trial of telehealth home monitoring. The sample included mothers (n = 148) of infants with congenital heart disease who provided data at four months post-discharge. Ten imputations were generated using fully conditional specification methods to address missing data and were combined. All analyses were performed on the imputed data. Mothers’ QOL was the main outcome of the analysis, as measured by the Ulm Quality of Life Inventory for Parents. Predictors on QOL were identified based on the World Health Organization QOL framework which recognizes the multidimensional domains influencing QOL that include personal factors, environmental factors, and physical factors related to disease and functioning. Results: The treatment and control groups did not differ on any study variable, thus data were collapsed and analyzed together. Final multivariable model found that the combination of dyadic adjustment, social support, parenting stress, and post-traumatic stress symptoms explained approximately three-quarters of the variance in QOL scores. Conclusions: QOL for mothers of infants with congenital heart disease is largely influenced by psychosocial factors. Future research targeted toward improving maternal QOL should include psychosocial interventions that address social networks and stress.

Original languageEnglish
Pages (from-to)324-331
Number of pages8
JournalWorld journal for pediatric & congenital heart surgery
Issue number3
StatePublished - May 2022

Bibliographical note

Publisher Copyright:
© The Author(s) 2022.


  • congenital heart disease
  • infants
  • maternal stress
  • mothers
  • quality of life
  • social support

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pediatrics, Perinatology, and Child Health


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