Punica granatum: Heuristic treatment for diabetes mellitus

Sarah Rachel Katz, Robert A. Newman, Ephraim Philip Lansky

Research output: Contribution to journalShort surveypeer-review


The current diabetes epidemic is a global concern with readily available effective therapies or preventative measures in demand. One natural product with such potential is the pomegranate (Punica granatum), with hypoglycemic activity noted from its flowers, seeds, and juice in canons of the traditional folk medicines of India. The mechanisms for such effects are largely unknown, though recent research suggests pomegranate flowers and juice may prevent diabetic sequelae via peroxisome proliferator-activated receptor-γ binding and nitric oxide production. Pomegranate compounds associated with antidiabetic effects include oleanolic, ursolic, and gallic acids. Pomegranate fractions and their active compounds hold potential and are worthy of further investigations as safe and effective medical treatments for diabetes mellitus and its pathological consequences.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalJournal of Medicinal Food
Issue number2
StatePublished - Jun 2007
Externally publishedYes


  • Antioxidant
  • Insulin resistance
  • Peroxisome proliferator-activated receptor-γ
  • Pomegranate
  • Triterpene

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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