Psychological factors correlate meaningfully with percent-monocytes among acute coronary syndrome patients

Yori Gidron, Tikva Armon, Harel Gilutz, Mahmoud Huleihel

Research output: Contribution to journalArticlepeer-review


Recent research demonstrates the importance of inflammatory parameters in the etiology and prognosis of the acute coronary syndrome (ACS). This study explored relations between psychological factors and immunological parameters routinely measured among ACS patients. Forty-two ACS patients completed questionnaires assessing perceived-control, emotional support, hostility, and life-events 2-4 days after hospitalization. Data on total leukocytes and percentages (%) of monocytes, %neutrophils, and %lymphocytes upon admission to hospital were collected from computerized medical charts as well as various biomedical information and risk-factors (e.g., diagnosis, left-ventricle - LV functioning, smoking, and hypertension). Of all significant biomedical variables, LV-function and arrival-time correlated uniquely with total leukocytes. Controlling for LV-function and arrival-time, hostility and life-events positively correlated with %monocytes, and perceived-control and emotional-support inversely correlated with %monocytes. Emotional-support was positively correlated and life-events were negatively correlated with %neutrophils. Macrophages play a pivotal role in plaque instability, the trigger of an ACS. This initiating role, and our finding of a relationship between recruitment of monocytes and a poor psychosocial profile, predictive of ACS, are consistent with a PNI component in the pathophysiology of ACS.

Original languageEnglish
Pages (from-to)310-315
Number of pages6
JournalBrain, Behavior, and Immunity
Issue number4
StatePublished - Aug 2003
Externally publishedYes


  • Acute coronary syndrome
  • Leukocytes
  • Monocytes
  • Psychological factors
  • Psychoneuroimmunology

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience
  • Immunology


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