Abstract
The protective effect of exogenous heat shock protein 70 kDa (Hsp70) has been studied on the model of acute myocardial infarction in laboratory Sprague-Dawley rats after a single intravenous injection of Hsp70 at a dose of 250 μg/kg. The results showed that protein reduced the infarction size from 39.0 ± 3.4 to 24.6 ± 3.9% as compared to control animals. It was suggested that extracellular Hsp70 possesses cardioprotector properties.
| Original language | English |
|---|---|
| Pages (from-to) | 3-7 |
| Number of pages | 5 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 82 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2019 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 Izdatel'stvo Meditsina. All rights reserved.
Keywords
- Acute myocardial infarction
- Heat shock protein
- Hsp70
- Ischemia
- Preconditioning
- Rats
- Reperfusion
ASJC Scopus subject areas
- Toxicology
- Pharmacology