Prospective relationship between hemispheric lateralisation and CD4+ T cells in human immunodeficiency virus type 1

Rachel C. Sumner, Alexander V. Nowicky, Andrew Parton, Carolien Wylock, Renata Cserjesi, Benjamin Fischler, Patrick Lacor, Yori Gidron

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Neuromodulation of the immune system has been proposed to be influenced by hemispheric lateralisation (HL). The present study tested whether HL predicted CD4+ levels, statistically controlling for confounders. Methods: Employing two assessments of HL, 68 human immunodeficiency virus (HIV)-1+ patients were followed prospectively. Numerous exclusion criteria and confounder assessments were employed (e.g. age/medication). Results: Left HL significantly positively predicted CD4+ levels at follow-up, and this was qualified by medication (HAART) status: only in HAART-naïve patients did HL predict CD4 levels. Furthermore, HL significantly predicted whether patients had clinically significantly high/low CD4+ counts. Conclusions: Using a more rigorous methodology than a previous study, the present work partly corroborated the theory of HL influences on immunity, extended it to HIV immunity and identified a possible moderator: HAART medication. Implications for future research and treatments are provided.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalNeuroImmunoModulation
Volume21
Issue number1
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • CD4
  • HAART
  • HIV
  • Hemispheric lateralisation
  • Neuromodulation

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Neurology
  • Endocrinology
  • Immunology

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