Abstract
Background: There is growing evidence linking nonalcoholic fatty liver disease (NAFLD) with reduced glomerular filtration rate (GFR). Living kidney donors do not have underlying kidney disease, but have reduced GFR as a result of nephrectomy. Whether kidney donation is associated with a higher risk for development or progression of NAFLD is currently unknown. Methods: Retrospective evaluation of metabolic parameters and sonographic evidence of NAFLD were performed in 232 living kidney donors and 162 healthy controls. Results: A total of 25 donors and 44 controls had NAFLD at baseline. During a mean follow-up of 6.8 years, 6 donors (24%) and 17 controls (38.6%) (P =.29) had a remission of NAFLD, related with decreased body mass index (BMI). The progression of NAFLD fibrosis score was similar in both groups. New onset of NAFLD was observed in 14 (6.8%) donors and 13 (11.01%) controls (P =.211), and was related to increased BMI and a higher baseline Fatty Liver Index score. Neither eGFR nor urine albumin excretion in the donors were related to new onset or progression of NAFLD. Conclusions: Reduced kidney function secondary to kidney donation is not associated with increased incidence or progression of NAFLD.
Original language | English |
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Article number | e13240 |
Journal | Clinical Transplantation |
Volume | 32 |
Issue number | 5 |
DOIs | |
State | Published - May 2018 |
Bibliographical note
Publisher Copyright:© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Keywords
- glomerular filtration rate
- living kidney donors
- metabolic syndrome
- nonalcoholic fatty liver disease
ASJC Scopus subject areas
- Transplantation