Priming stimulation in the basolateral amygdala modulates synaptic plasticity in the rat dentate gyrus

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effects of basolateral amygdala (BLA) priming on long-term potentiation (LTP) in the dentate gyrus (DG). In the control animals, the induction of high-frequency stimulation (HFS) to the perforant path (PP) resulted in hippocampal LTP at all the time intervals tested. A priming stimulation to the BLA prior to the application of HFS to the PP resulted in the enhancement of the excitatory post-synaptic potential (EPSP)- LTP and population spike (PS)-LTP in the DG from 90-min post-HFS onwards. These findings suggest that the amygdala has a potential role in the modulation of some aspects of memory that are mediated by the hippocampus.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalNeuroscience Letters
Volume270
Issue number2
DOIs
StatePublished - 30 Jul 1999

Bibliographical note

Funding Information:
The work was supported by a BSF grant No. 96–291 to G.R.-L.

Keywords

  • Amygdalo-hippocampal interaction
  • Basolateral amygdala
  • Dentate gyrus
  • Hippocampus
  • Long-term potentiation
  • Memory
  • Rat
  • Synaptic plasticity

ASJC Scopus subject areas

  • General Neuroscience

Fingerprint

Dive into the research topics of 'Priming stimulation in the basolateral amygdala modulates synaptic plasticity in the rat dentate gyrus'. Together they form a unique fingerprint.

Cite this