Abstract
We investigated the effects of basolateral amygdala (BLA) priming on long-term potentiation (LTP) in the dentate gyrus (DG). In the control animals, the induction of high-frequency stimulation (HFS) to the perforant path (PP) resulted in hippocampal LTP at all the time intervals tested. A priming stimulation to the BLA prior to the application of HFS to the PP resulted in the enhancement of the excitatory post-synaptic potential (EPSP)- LTP and population spike (PS)-LTP in the DG from 90-min post-HFS onwards. These findings suggest that the amygdala has a potential role in the modulation of some aspects of memory that are mediated by the hippocampus.
Original language | English |
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Pages (from-to) | 83-86 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 270 |
Issue number | 2 |
DOIs | |
State | Published - 30 Jul 1999 |
Bibliographical note
Funding Information:The work was supported by a BSF grant No. 96–291 to G.R.-L.
Keywords
- Amygdalo-hippocampal interaction
- Basolateral amygdala
- Dentate gyrus
- Hippocampus
- Long-term potentiation
- Memory
- Rat
- Synaptic plasticity
ASJC Scopus subject areas
- General Neuroscience