Primary peritoneal serous carcinoma in men: A rare and non-BRCA-associated entity

Susan L. Neuhausen, Hagit Shani, Lital Keinan Boker, Linda Steele, Barbara G. Silverman, Laura Ottini, Valentina Silvestri, Yael Laitman, Jacob Korach, Tamar Perri, Eitan Friedman

Research output: Contribution to journalArticlepeer-review


Background: Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. Materials and Methods: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed. Results: In the INCR dataset, 220 entries for C48.2 code were noted, with only one male (male:female ratio=0.0045). In the SEER dataset for histology codes of papillary/serous/adenocarcinoma, 2,673 cases were recorded, with five males (male:female ratio=0.0018). None of the recorded US or Italian male BRCA carriers or MBC, or Israeli male BRCA carriers was diagnosed with PPSC. Conclusion: PPSC is a rare neoplasm, seemingly not associated with BRCA mutations in men, and fallopian tube epithelial cell implants may contribute to its development.

Original languageEnglish
Pages (from-to)3069-3072
Number of pages4
JournalAnticancer Research
Issue number6
StatePublished - Jun 2017
Externally publishedYes


  • Cancer risk
  • Male BRCA mutations
  • Ovarian cancer
  • PPSC
  • Primary peritoneal serous carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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