Prevention of Conversion of Tumor Dormancy into Proliferative Metastases

Dalit Barkan, Ann F. Chambers

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Late recurrences of cancer are believed to be due to dormant disease that can persist for long periods following apparently successful treatment of a primary tumor. Clinical tumor dormancy thus creates uncertainty for cancer patients and their physicians, who cannot be certain that their cancer will not recur. We have a poor understanding about which individual patients are at risk for cancer recurrence following a period of tumor dormancy. Thus, in spite of the clinical importance of tumor dormancy, much remains to be learned about the mechanisms responsible for induction of, and release from, dormancy. Here we consider the clinical problem of tumor dormancy and discuss evolving ideas of how tumor dormancy and reinitiation of growth may be regulated, both naturally in the body and therapeutically. A better understanding of mechanisms by which dormancy can be regulated may suggest new therapeutic approaches to either eliminate dormant cancer cells or promote the maintenance of dormancy.

Original languageEnglish
Title of host publicationCirculating Tumor Cells
EditorsRichard J. Cote, Ram Datar
Place of PublicationNY
PublisherSpringer Nature
Number of pages17
ISBN (Print)978-1-4939-3361-7
StatePublished - 2016

Publication series

NameCurrent Cancer Research
ISSN (Print)2199-2584
ISSN (Electronic)2199-2592

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York.


  • Angiogenesis
  • Cellular dormancy
  • Disseminated tumor cells
  • Immune regulation
  • Metastasis
  • Molecular characterization
  • Tumor dormancy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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