Preventing Noise Induced Otoacoustic Emission Loss By Increasing Magnesium (Mg2+) Intake In Guinea-Pigs

Joseph Attias; Ian Bresloff; Heidemarie Haupt; Fred Scheibe; Hartmut Ising

doi:10.1515/JBCPP.2003.14.2.119

Preventing Noise Induced Otoacoustic Emission Loss By Increasing Magnesium (Mg²⁺) Intake In Guinea-Pigs

Joseph Attias, Ian Bresloff, Heidemarie Haupt, Fred Scheibe, Hartmut Ising

Department of Communication Sciences and Disorders

Research output: Contribution to journal › Article › peer-review

Abstract

This study aimed to explore the effects of increased intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg²⁺) intake (39 mmol Mg²⁺)/1 in drinking water) and 12 without the Mg²⁺) additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg²⁺)-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg²⁺) animals (controls). In addition, a relationship was found between the Mg²⁺) level and the emission loss. The post-exposure measures may result from the effect of on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg²⁺) levels will exacerbate noise induced hearing loss (NIHL), and increased Mg²⁺) intake provides a significant biological cochlear protective effect.

Original language	English
Pages (from-to)	119-136
Number of pages	18
Journal	Journal of Basic and Clinical Physiology and Pharmacology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1515/JBCPP.2003.14.2.119
State	Published - 2003

Keywords

guinea-pig
hearing loss
magnesium
noise
otoacoustic emissions

ASJC Scopus subject areas

Physiology
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1515/JBCPP.2003.14.2.119

Cite this

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title = "Preventing Noise Induced Otoacoustic Emission Loss By Increasing Magnesium (Mg2+) Intake In Guinea-Pigs",

abstract = "This study aimed to explore the effects of increased intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg2+) intake (39 mmol Mg2+)/1 in drinking water) and 12 without the Mg2+) additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg2+)-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg2+) animals (controls). In addition, a relationship was found between the Mg2+) level and the emission loss. The post-exposure measures may result from the effect of on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg2+) levels will exacerbate noise induced hearing loss (NIHL), and increased Mg2+) intake provides a significant biological cochlear protective effect.",

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AU - Ising, Hartmut

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N2 - This study aimed to explore the effects of increased intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg2+) intake (39 mmol Mg2+)/1 in drinking water) and 12 without the Mg2+) additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg2+)-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg2+) animals (controls). In addition, a relationship was found between the Mg2+) level and the emission loss. The post-exposure measures may result from the effect of on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg2+) levels will exacerbate noise induced hearing loss (NIHL), and increased Mg2+) intake provides a significant biological cochlear protective effect.

AB - This study aimed to explore the effects of increased intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg2+) intake (39 mmol Mg2+)/1 in drinking water) and 12 without the Mg2+) additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg2+)-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg2+) animals (controls). In addition, a relationship was found between the Mg2+) level and the emission loss. The post-exposure measures may result from the effect of on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg2+) levels will exacerbate noise induced hearing loss (NIHL), and increased Mg2+) intake provides a significant biological cochlear protective effect.

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