Preventing Noise Induced Otoacoustic Emission Loss By Increasing Magnesium (Mg2+) Intake In Guinea-Pigs

Joseph Attias, Ian Bresloff, Heidemarie Haupt, Fred Scheibe, Hartmut Ising

Research output: Contribution to journalArticlepeer-review


This study aimed to explore the effects of increased intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg2+) intake (39 mmol Mg2+)/1 in drinking water) and 12 without the Mg2+) additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg2+)-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg2+) animals (controls). In addition, a relationship was found between the Mg2+) level and the emission loss. The post-exposure measures may result from the effect of on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg2+) levels will exacerbate noise induced hearing loss (NIHL), and increased Mg2+) intake provides a significant biological cochlear protective effect.

Original languageEnglish
Pages (from-to)119-136
Number of pages18
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number2
StatePublished - 2003


  • guinea-pig
  • hearing loss
  • magnesium
  • noise
  • otoacoustic emissions

ASJC Scopus subject areas

  • Drug Discovery
  • Physiology
  • Pharmacology


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