Prenatal diagnosis and outcome of isolated interrupted inferior vena cava

Moshe Bronshtein, Nizar Khatib, Zeev Blumenfeld

Research output: Contribution to journalArticlepeer-review


Objective: Report our experience in prenatal diagnosis of 11 cases of interrupted inferior vena cava, summarize the clinical significance and implications of this variant. Study Design: Retrospective analysis of 11 fetuses diagnosed with interrupted inferior vena cava, of 55,457 pregnant women who underwent extensive fetal anomaly scan during 20 years. Results: Eight of the 11 fetuses with interrupted inferior vena cava had a completely normal outcome. One had also normal outcome but abnormal function of the spleen. One had multiple abnormalities, and 1 case was lost to follow up. Conclusion: The incidence of IIVC is 1:5000. In the vast majority (90%) of the cases, it is an isolated variant not associated with isomerism or fetal anomalies. In all the cases of isolated interrupted inferior vena cava, the outcome is favorable. In 10% of isolated interrupted inferior vena cava, abnormal function of the spleen may be detected after delivery, necessitating antipneumococcal vaccination.

Original languageEnglish
Pages (from-to)398.e1-398.e4
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
StatePublished - Apr 2010
Externally publishedYes


  • azygos vein
  • fetal malformations
  • interrupted inferior vena cava
  • prenatal diagnosis
  • transvaginal sonography

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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