Premenstrual distress predicts panic-relevant responding to a CO2 challenge among young adult females

Yael I. Nillni, Kelly J. Rohan, Amit Bernstein, Michael J. Zvolensky

Research output: Contribution to journalArticlepeer-review


The current study examined the incremental validity of self-reported premenstrual distress in predicting panic responsivity (self-reported panic symptoms and skin conductance response frequency; SCR) following inhalation of 10% CO2-enriched air. A community sample of young adult women (n=46) completed questionnaires assessing substance use patterns, premenstrual symptoms and distress, and anxiety sensitivity and underwent a laboratory biological challenge procedure (4-min 10% CO2-enriched air inhalation). As hypothesized, higher premenstrual distress scores significantly predicted greater self-reported panic symptoms following the CO2 challenge above and beyond other theoretically relevant variables (anxiety sensitivity, cigarette use, and alcohol consumption). In predicting SCR, premenstrual distress exhibited only a trend towards statistical significance. These findings provide preliminary evidence that premenstrual symptoms may serve as a potential risk factor to experience more intense panic symptoms in response to perturbations in bodily sensations.

Original languageEnglish
Pages (from-to)416-422
Number of pages7
JournalJournal of Anxiety Disorders
Issue number4
StatePublished - May 2010


  • CO challenge
  • Panic
  • Premenstrual distress

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Premenstrual distress predicts panic-relevant responding to a CO2 challenge among young adult females'. Together they form a unique fingerprint.

Cite this