Prefrontal Oxytocin is Involved in Impairments in Prefrontal Plasticity and Social Memory Following Acute Exposure to High Fat Diet in Juvenile Animals

Aseel Yaseen, Kuldeep Shrivastava, Zohar Zuri, Ossama A. Hatoum, Mouna Maroun

Research output: Contribution to journalArticlepeer-review

Abstract

Juvenility represents a critical developmental phase during which exposure to a high fat diet (HFD) can severely modify cognitive and emotional functioning. The purpose of this study was to address how short and acute exposure to a HFD during juvenility affects social memory recognition and prefrontal long-Term potentiation (LTP). As LTP and social memory depend on the neuromodulator oxytocin (OXY) and due to its role in metabolism, we also examined the effects of OXY in mediating HFD-induced alterations in social memory and LTP. Our results show that short exposure to a HFD during juvenility impairs social preference memory and prefrontal LTP. Interestingly, whereas systemic injections of OXY reversed the impairments in HFD-fed animals and impaired LTP and memory in control animals; prefrontal injections of the OXY agonist TGOT reversed the effects in HFD animals without affecting control animals. Exposure to HFD was associated with a reduction in the levels of OXY in the prefrontal compared to control animals. Interestingly, the restoration of social memory by TGOT in HFD animals was also associated with normalization of OXY in the prefrontal. These results point to a role that prefrontal OXY has in mediating the effects of HFD on memory and plasticity.

Original languageEnglish
Article numberbhy070
Pages (from-to)1900-1909
Number of pages10
JournalCerebral Cortex
Volume29
Issue number5
DOIs
StatePublished - May 2019

Bibliographical note

Publisher Copyright:
© 2018 The Author(s) 2018. Published by Oxford University Press. All rights reserved.

Keywords

  • LTP
  • TGOT
  • juveniles
  • neuro-obesity
  • prefrontal
  • social preference

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

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