Preferred positions of aa and tt dinucleotides in aligned nucleosomal dna sequences

I. Ioshikhes, A. Bolshoy, E. N. Trifonov

Research output: Contribution to journalArticlepeer-review


Multiple alignment of 118 nucleosomal DNA sequences by maximizing simultaneously match of AA dinucleotides and match of TT dinucleotides results in a pattern of the dinucleotide distributions which is characteristic of the nucleosomal DNA sequences. The AA dinucleotides are found to be distributed symmetrically relative to the TT dinucleotide distribution, around the middle point of the nucleosomal DNA sequence. The distances between major peaks of the distributions are multiples of about 10.4 bases. The peaks of the TT distribution are shifted by 6 bases downstream from the peaks of the AA distribution.

Original languageEnglish
Pages (from-to)1111-1118
Number of pages8
JournalJournal of Biomolecular Structure and Dynamics
Issue number6
StatePublished - Jun 1992
Externally publishedYes

Bibliographical note

Funding Information:
This work has been supported by Ministry of Absorbtion and by Ministry of Science and Technology. Authors appreciate discussions with Dr. L. Garber.

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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