Pomegranate (Punica granatum) seed linolenic acid isomers: Concentration-dependent modulation of estrogen receptor activity

Hoang Ngoc Ai Tran; Soo Young Bae; Bang Ho Song; Bang Hyo Lee; Young Seok Bae; Young Ho Kim; Ephraim Philip Lansky; Robert A. Newman

doi:10.3109/07435800903524161

Pomegranate (Punica granatum) seed linolenic acid isomers: Concentration-dependent modulation of estrogen receptor activity

Hoang Ngoc Ai Tran, Soo Young Bae, Bang Ho Song, Bang Hyo Lee, Young Seok Bae, Young Ho Kim, Ephraim Philip Lansky, Robert A. Newman

Research output: Contribution to journal › Article › peer-review

Abstract

Pomegranate (Punica granatum) seed linolenic acid isomers were evaluated as selective estrogen receptor modulators (SERMs) in vitro. Punicic acid (PA) inhibited (IC₅₀) estrogen receptor (ER) α at 7.2 μM, ERβ at 8.8 μM; α-eleostearic acid (AEA) inhibited ERαERβ at 6.57.8 μM. PA (not AEA) agonized ERαERβ (EC₅₀) at 1.82 μM, antagonizing at 10180 μM. AEA antagonized ERαERβ at 150140 μM. PA and AEA induced ERα and ERβ mRNA expression in MCF-7, but not in MDA-MB-231. Overall, the results show PA and AEA are SERMs.

Original language	English
Pages (from-to)	1-16
Number of pages	16
Journal	Endocrine Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.3109/07435800903524161
State	Published - Feb 2010
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Grant of Agricultural R&D Promotion center (ARPC, 2002–2005), Republic of Korea. We thank Professor Gunter Daxenbichler, Univ-Klink fur Frauenheikunde, Innsbruck, Germany for the kind gift of breast cancer cell lines.

Keywords

Breast cancer
Conjugated linolenic acid
Phytoestrogen
Pomegranate (Punica granatum)
Proliferation
Punicic acid
Selective estrogen receptor modulator

ASJC Scopus subject areas

Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/07435800903524161

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title = "Pomegranate (Punica granatum) seed linolenic acid isomers: Concentration-dependent modulation of estrogen receptor activity",

abstract = "Pomegranate (Punica granatum) seed linolenic acid isomers were evaluated as selective estrogen receptor modulators (SERMs) in vitro. Punicic acid (PA) inhibited (IC50) estrogen receptor (ER) α at 7.2 μM, ERβ at 8.8 μM; α-eleostearic acid (AEA) inhibited ERαERβ at 6.57.8 μM. PA (not AEA) agonized ERαERβ (EC50) at 1.82 μM, antagonizing at 10180 μM. AEA antagonized ERαERβ at 150140 μM. PA and AEA induced ERα and ERβ mRNA expression in MCF-7, but not in MDA-MB-231. Overall, the results show PA and AEA are SERMs.",

keywords = "Breast cancer, Conjugated linolenic acid, Phytoestrogen, Pomegranate (Punica granatum), Proliferation, Punicic acid, Selective estrogen receptor modulator",

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note = "Funding Information: This work was supported by the Grant of Agricultural R&D Promotion center (ARPC, 2002–2005), Republic of Korea. We thank Professor Gunter Daxenbichler, Univ-Klink fur Frauenheikunde, Innsbruck, Germany for the kind gift of breast cancer cell lines.",

year = "2010",

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doi = "10.3109/07435800903524161",

language = "English",

volume = "35",

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journal = "Endocrine Research",

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AU - Tran, Hoang Ngoc Ai

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AU - Song, Bang Ho

AU - Lee, Bang Hyo

AU - Bae, Young Seok

AU - Kim, Young Ho

AU - Lansky, Ephraim Philip

AU - Newman, Robert A.

N1 - Funding Information: This work was supported by the Grant of Agricultural R&D Promotion center (ARPC, 2002–2005), Republic of Korea. We thank Professor Gunter Daxenbichler, Univ-Klink fur Frauenheikunde, Innsbruck, Germany for the kind gift of breast cancer cell lines.

PY - 2010/2

Y1 - 2010/2

N2 - Pomegranate (Punica granatum) seed linolenic acid isomers were evaluated as selective estrogen receptor modulators (SERMs) in vitro. Punicic acid (PA) inhibited (IC50) estrogen receptor (ER) α at 7.2 μM, ERβ at 8.8 μM; α-eleostearic acid (AEA) inhibited ERαERβ at 6.57.8 μM. PA (not AEA) agonized ERαERβ (EC50) at 1.82 μM, antagonizing at 10180 μM. AEA antagonized ERαERβ at 150140 μM. PA and AEA induced ERα and ERβ mRNA expression in MCF-7, but not in MDA-MB-231. Overall, the results show PA and AEA are SERMs.

AB - Pomegranate (Punica granatum) seed linolenic acid isomers were evaluated as selective estrogen receptor modulators (SERMs) in vitro. Punicic acid (PA) inhibited (IC50) estrogen receptor (ER) α at 7.2 μM, ERβ at 8.8 μM; α-eleostearic acid (AEA) inhibited ERαERβ at 6.57.8 μM. PA (not AEA) agonized ERαERβ (EC50) at 1.82 μM, antagonizing at 10180 μM. AEA antagonized ERαERβ at 150140 μM. PA and AEA induced ERα and ERβ mRNA expression in MCF-7, but not in MDA-MB-231. Overall, the results show PA and AEA are SERMs.

KW - Breast cancer

KW - Conjugated linolenic acid

KW - Phytoestrogen

KW - Pomegranate (Punica granatum)

KW - Proliferation

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KW - Selective estrogen receptor modulator

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JO - Endocrine Research

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Pomegranate (Punica granatum) seed linolenic acid isomers: Concentration-dependent modulation of estrogen receptor activity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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