Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™

Ephraim Philip Lansky, Gregory Harrison, Paul Froom, Wen G. Jiang

Research output: Contribution to journalArticlepeer-review

Abstract

Four pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit (Punica granatum), and each belonging to different representative chemical classes and showing known anticancer activities, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel™ artificial membranes. All compounds significantly inhibited invasion when employed individually. When C, P, and L were equally combined at the same gross dosage (4 μ g/ml) as when the compounds were tested individually, a supradditive inhibition of invasion was observed, measured by the Kruskal-Wallis non-parametric test.

Original languageEnglish
Pages (from-to)121-122
Number of pages2
JournalInvestigational New Drugs
Volume23
Issue number2
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Caffeic acid
  • Conjugated fatty acid
  • Ellagic acid
  • Luteolin
  • Punicic acid

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology
  • Pharmacology

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