TY - JOUR
T1 - Pneumococcal meningitis in adults after introduction of PCV7 and PCV13, Israel, july 2009–june 2015
AU - Israeli Adult Invasive Pneumococcal Disease Group
AU - Regev-Yochay, Gili
AU - Reisenberg, Klaris
AU - Katzir, Michal
AU - Wiener-Well, Yonit
AU - Rahav, Galia
AU - Strahilevitz, Jacob
AU - Istomin, Valery
AU - Tsyba, Evgenia
AU - Peretz, Avi
AU - Khakshoor, Shirley
AU - Dagan, Ron
N1 - Publisher Copyright:
© 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2018/7
Y1 - 2018/7
N2 - The indirect effect of pneumococcal conjugate vaccine on adult pneumococcal meningitis has not been thoroughly investigated. We present data from active surveillance on pneumococcal meningitis in adults in Israel occurring during July 2009–June 2015. Pneumococcal meningitis was diagnosed for 221 patients, 9.4% of all invasive pneumococcal disease (IPD) cases. Although overall IPD incidence decreased during the study period, meningitis increased nonsignificantly from 0.66 to 0.85 cases/100,000 population. Incidence of vaccine type (VT) pneumococcal meningitis (VT13) decreased by 70%, but non-VT13 pneumococcal meningitis increased from 0.32 to 0.75 cases/100,000 population (incident rate ratio 2.35, 95% CI 1.27–4.35). Pneumococcal meningitis patients were younger and healthier than nonmeningitis IPD patients, and 20.2% had a history of previous head surgery or cerebrospinal fluid leak compared with <2.0% of nonmeningitis patients (p<0.0001). Non-VT13 types that rarely cause IPD (15B/C, 6C, 23A, 23B, 24F) seem to be emerging as common causes of meningitis.
AB - The indirect effect of pneumococcal conjugate vaccine on adult pneumococcal meningitis has not been thoroughly investigated. We present data from active surveillance on pneumococcal meningitis in adults in Israel occurring during July 2009–June 2015. Pneumococcal meningitis was diagnosed for 221 patients, 9.4% of all invasive pneumococcal disease (IPD) cases. Although overall IPD incidence decreased during the study period, meningitis increased nonsignificantly from 0.66 to 0.85 cases/100,000 population. Incidence of vaccine type (VT) pneumococcal meningitis (VT13) decreased by 70%, but non-VT13 pneumococcal meningitis increased from 0.32 to 0.75 cases/100,000 population (incident rate ratio 2.35, 95% CI 1.27–4.35). Pneumococcal meningitis patients were younger and healthier than nonmeningitis IPD patients, and 20.2% had a history of previous head surgery or cerebrospinal fluid leak compared with <2.0% of nonmeningitis patients (p<0.0001). Non-VT13 types that rarely cause IPD (15B/C, 6C, 23A, 23B, 24F) seem to be emerging as common causes of meningitis.
UR - http://www.scopus.com/inward/record.url?scp=85050498894&partnerID=8YFLogxK
U2 - 10.3201/eid2407.170721
DO - 10.3201/eid2407.170721
M3 - Article
C2 - 29912694
AN - SCOPUS:85050498894
SN - 1080-6040
VL - 24
SP - 1275
EP - 1284
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 7
ER -