Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke

Galit Weinstein, Alexa S. Beiser, Sarah R. Preis, Paul Courchesne, Vincent Chouraki, Daniel Levy, Sudha Seshadri

Research output: Contribution to journalArticlepeer-review


Introduction: Genetic variation in the clusterin gene has been associated with Alzheimer Disease (AD), and the clusterin protein is thought to play a mechanistic role. We explored the associations of clusterin plasma levels with incident dementia, AD, and stroke. Methods: Plasma clusterin was assessed in 1532 nondemented participants from the Framingham Study Offspring cohort between 1998 and 2001 (mean age, 69 ± 6; 53% women). We related clusterin levels to risk of incident dementia, AD, and stroke using Cox-proportional hazards models and examined potential interactions. Results: A significant interaction of plasma clusterin levels with age was observed. Clusterin was significantly associated with increased risk of dementia among elderly persons (>80 years; hazard ratio [HR], 95% confidence interval = 6.25, 1.64-23.89; P =.007) and with decreased risk of dementia (HR = 0.53, 0.32-0.88; P =.013) and stroke (HR = 0.78, 0.63-0.97; P =.029) among younger participants. Discussion: The association between plasma clusterin levels and risk of dementia and stroke may be modified by age or an age-related factor.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
StatePublished - 2016
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the dedication of the Framingham Heart Study participants, the National Heart, Lung and Blood Institute's Framingham Heart Study (Contract No. N01-HC-25195) and by grants from the National Institute of Neurological Disorders and Stroke ( NS017950 ), the National Heart, Lung and Blood Association ( HL93029 , U01HL 096917 ) and the National Institute on Aging ( AG008122 , AG016495 , AG033193 , AG031287 , U01AG049505 , U01AG049607 ) and by the Division of Intramural Research, National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, the National Heart Lung and Blood Institute, the National Institute on Aging, or the National Institutes of Health.

Publisher Copyright:
© 2016 The Authors.


  • Alzheimer's disease
  • Dementia
  • Epidemiology
  • Plasma clusterin
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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