Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke

Galit Weinstein, Alexa S. Beiser, Sarah R. Preis, Paul Courchesne, Vincent Chouraki, Daniel Levy, Sudha Seshadri

Research output: Contribution to journalArticlepeer-review


Introduction: Genetic variation in the clusterin gene has been associated with Alzheimer Disease (AD), and the clusterin protein is thought to play a mechanistic role. We explored the associations of clusterin plasma levels with incident dementia, AD, and stroke. Methods: Plasma clusterin was assessed in 1532 nondemented participants from the Framingham Study Offspring cohort between 1998 and 2001 (mean age, 69 ± 6; 53% women). We related clusterin levels to risk of incident dementia, AD, and stroke using Cox-proportional hazards models and examined potential interactions. Results: A significant interaction of plasma clusterin levels with age was observed. Clusterin was significantly associated with increased risk of dementia among elderly persons (>80 years; hazard ratio [HR], 95% confidence interval = 6.25, 1.64-23.89; P =.007) and with decreased risk of dementia (HR = 0.53, 0.32-0.88; P =.013) and stroke (HR = 0.78, 0.63-0.97; P =.029) among younger participants. Discussion: The association between plasma clusterin levels and risk of dementia and stroke may be modified by age or an age-related factor.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
StatePublished - 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 The Authors.


  • Alzheimer's disease
  • Dementia
  • Epidemiology
  • Plasma clusterin
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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