Plasma Antioxidants and Lipid Peroxidation in Acute Myocardial Infarction and Thrombolysis

Yishai Levy, Peter Bartha, Ami Ben-Amotz, J. Gerald Brook, Gertrude Dankner, Shai Lin, Haim Hammerman

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The aim of this study was to investigate the balance between prooxidative and protective mechanisms in patients with acute myocardial infarction (AMI) throughout streptokinase (STK) therapy.

Methods: Patients who presented to coronary care unit within 3 hours of infarction were followed. Blood was collected before, 2 and 24 hours post STK. Plasma lipid peroxidation was analyzed by a free radical generating system (AAPH) and malondialdehyde equivalents and conjugated dienes quantitated. Plasma vitamins A, E and β-carotene, were analyzed by HPLC. Patients’ results were compared with those from age-matched, healthy control subjects.

Results: In 38 patients with AMI, baseline plasma antioxidant vitamin concentration was reduced compared with a healthy control group. Upon STK therapy, there was a significant drop in plasma vitamin E concentration. Successful reperfusion was followed by an increased plasma oxidizability. Plasma lipids were not significantly different in the AMI patients except for a lower HDL-cholesterol concentration.

Conclusions: Patients with AMI showed a drop in plasma antioxidant vitamins. Upon thrombolysis, there was an enhanced lipid peroxidation. These alterations indicate the significance of free radical generation processes in reperfusion injury in AMI patients, and suggest the potential involvement of antioxidants in the management of AMI treated by thrombolysis.
Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalJournal of the American College of Nutrition
Volume17
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Acute myocardial infarction
  • Antioxidants
  • Lipid peroxidation
  • Thrombolysis

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)

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