Piroxicam positively-charged emulsion protects against corneal alkali burn in a rabbit model

S. H. Klang, C. S. Siganos, S. Benita, J. Frucht-Pery

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Purpose. To evaluate the efficacy of topical positively-charged emulsion (PCE) of piroxicam (NSAID) in acute alkali burn in the cornea of a rabbit. Methods. Albino rabbits (n=36) were anesthetized and alkali burn (1N NaOH for 1 min.) was performed in the center of the cornea (7.5 mm diameter). Four groups of nine animals each were formed, and treated (double-masked) with topical piroxicam 0.1% PCE (Group 1), piroxicam 0.1% solution in saline (Group 2), blank PCE (Group 3) and saline 0.9% solution (Group 4). Drops were applied seven times/day for 28 days. Animals were evaluated twice weekly. Corneal ulcers were graded from 0 (no ulcer) to 5 (perforation) [G.S. Schultz et al: Invest Ophthalmol Vis Sci 33:3325-31, 1992]. Results. The range of cumulative ulceration scores was: 2 to 14.5 in Group 1, 1 to 18 in Group 2, 2.5 to 17 in Group 3, and 1 to 17.5 in Group 4. One descematocele or perforation occurred in Group 1, 3 in Group 2, 2 in Group 3, and 2 in Group 4. Ulceration scores in Group 1 were lower as compared with Group 2 (p<0.05), Group 3 (p<0.02), and Group 4 (p<0.05). Conclusions. Piroxicam positively-charged emulsion may be an adjunct treatment for corneal alkali burn.

Original languageEnglish
Pages (from-to)S77
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - 15 Feb 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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