Abstract
Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro- and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-β-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.
Original language | English |
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Pages (from-to) | 562-573 |
Number of pages | 12 |
Journal | Cell Reports |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - 3 Feb 2015 |
Bibliographical note
Publisher Copyright:© 2015 The Authors.
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology