TY - JOUR
T1 - Pharmacological values of medicinal mushrooms for prostate cancer therapy
T2 - The case of Ganoderma lucidum
AU - Mahajna, Jamal
AU - Dotan, Nesly
AU - Zaidman, Ben Zion
AU - Petrova, Roumyana D.
AU - Wasser, Solomon P.
PY - 2009/1
Y1 - 2009/1
N2 - Prostate cancer (PCa) is the most common male malignancy in many Western countries. Primary PCa is hormone dependent and is manageable by hormonal therapy. However, it rapidly develops to hormone-refractory tumors due to the accumulation of mutations in the androgen receptor and/or the acquisition of alternative cellular pathways that support proliferation and inhibit apoptosis of prostate cancer. To date, no effective therapy is available for clinically hormone-insensitive or hormone-refractory stages of prostate cancer.
AB - Prostate cancer (PCa) is the most common male malignancy in many Western countries. Primary PCa is hormone dependent and is manageable by hormonal therapy. However, it rapidly develops to hormone-refractory tumors due to the accumulation of mutations in the androgen receptor and/or the acquisition of alternative cellular pathways that support proliferation and inhibit apoptosis of prostate cancer. To date, no effective therapy is available for clinically hormone-insensitive or hormone-refractory stages of prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=58149159369&partnerID=8YFLogxK
U2 - 10.1080/01635580802379323
DO - 10.1080/01635580802379323
M3 - Review article
C2 - 19116872
AN - SCOPUS:58149159369
SN - 0163-5581
VL - 61
SP - 16
EP - 26
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 1
ER -
