Pharmacological and Immunohistochemical Evidence for Serotonergic Modulation of Cholinergic Nucleus Basalis Neurons

A. Khateb, P. Fort, A. Alonso, B. E. Jones, M. Mülethaler

Research output: Contribution to journalArticlepeer-review

Abstract

Identified electrophysiologically by low threshold bursts and transient outward rectification, cholinergic nucleus basalis neurons were recorded and labelled intracellularly in guinea‐pig basal forebrain slices. By means of a triple labelling immunofluorescent technique, serotonin‐immunoreactive fibres were visualized in close proximity to the soma and dendrites of the biocytin‐labelled, choline acetyl transferase (ChAT)‐immunoreactive cells. By bath application, 5‐hydroxytryptamine (5‐HT) produced a direct hyperpolarization of the identified cells which was mimicked by 5‐HT1A receptor agonists, suggesting that it may inhibit the tonic firing but also modulate the low threshold bursting of the cholinergic nucleus basalis neurons.

Original languageEnglish
Pages (from-to)541-547
Number of pages7
JournalEuropean Journal of Neuroscience
Volume5
Issue number5
DOIs
StatePublished - May 1993
Externally publishedYes

Keywords

  • 5‐HT receptor
  • guinea‐pig
  • low threshold spike
  • sleep
  • substantia innominata

ASJC Scopus subject areas

  • General Neuroscience

Fingerprint

Dive into the research topics of 'Pharmacological and Immunohistochemical Evidence for Serotonergic Modulation of Cholinergic Nucleus Basalis Neurons'. Together they form a unique fingerprint.

Cite this