Pentylenetetrazole-induced kindling is prevented by prior treatment with cysteamine

Edi Barkai, Hava Golan, Yoram Grossman, Michael J. Gutnick

Research output: Contribution to journalArticlepeer-review


We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect of kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - 21 Jun 1990
Externally publishedYes

Bibliographical note

Funding Information:
This Research was supported by a grant from the Deutsche Forschungsgemeinschaft (SFB 200).


  • Cortical kindling
  • Cysteamine
  • Limbic kindling
  • Pentylenetetrazole
  • Somatostatin

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Pentylenetetrazole-induced kindling is prevented by prior treatment with cysteamine'. Together they form a unique fingerprint.

Cite this