We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect of kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures.
Bibliographical noteFunding Information:
This Research was supported by a grant from the Deutsche Forschungsgemeinschaft (SFB 200).
- Cortical kindling
- Limbic kindling
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