Pentylenetetrazole-induced kindling is prevented by prior treatment with cysteamine

Edi Barkai; Hava Golan; Yoram Grossman; Michael J. Gutnick

doi:10.1016/0014-2999(90)90507-3

Pentylenetetrazole-induced kindling is prevented by prior treatment with cysteamine

Edi Barkai, Hava Golan, Yoram Grossman, Michael J. Gutnick

Research output: Contribution to journal › Article › peer-review

Abstract

We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect of kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures.

Original language	English
Pages (from-to)	167-169
Number of pages	3
Journal	European Journal of Pharmacology
Volume	182
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(90)90507-3
State	Published - 21 Jun 1990
Externally published	Yes

Bibliographical note

Funding Information:
This Research was supported by a grant from the Deutsche Forschungsgemeinschaft (SFB 200).

Keywords

Cortical kindling
Cysteamine
Limbic kindling
Pentylenetetrazole
Somatostatin

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(90)90507-3

Cite this

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title = "Pentylenetetrazole-induced kindling is prevented by prior treatment with cysteamine",

abstract = "We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect of kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures.",

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author = "Edi Barkai and Hava Golan and Yoram Grossman and Gutnick, {Michael J.}",

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AU - Barkai, Edi

AU - Golan, Hava

AU - Grossman, Yoram

AU - Gutnick, Michael J.

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N2 - We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect of kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures.

AB - We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect of kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures.

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KW - Limbic kindling

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KW - Somatostatin

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Pentylenetetrazole-induced kindling is prevented by prior treatment with cysteamine

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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