Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics

Keyphrases

• Pediatric 100%
• Trunk 100%
• Selection Dynamics 100%
• B Cell Repertoire 100%
• B Cells 66%
• B Cell Development 66%
• Adulthood 33%
• Sequence Data 33%
• Genomic DNA (gDNA) 33%
• Somatic Hypermutation 33%
• Selection Pressure 33%
• Human Lifespan 33%
• Steady State 33%
• Deep Sequencing 33%
• Adaptive Immune Response 33%
• Negative Selection 33%
• Relative Proportion 33%
• Clonal Selection 33%
• Naïve B Cells 33%
• Framework Regions 33%
• Multiple Datasets 33%
• Expanded Clones 33%
• Immunoglobulin Heavy Chain 33%
• B Cell Biology 33%
• Negative Selection Pressure 33%
• Novel Antigens 33%
• Germline 33%
• Internal Node 33%

Immunology and Microbiology

• B Cell 100%
• B Cell Development 50%
• Lifespan 25%
• Lineages 25%
• Somatic Hypermutation 25%
• Steady State 25%
• Clonal Selection 25%
• Adaptive Immune System 25%
• Naive B Cell 25%
• Framework Region 25%
• Immunoglobulin Heavy Chain 25%
• Antigen 25%
• Germ Cell 25%
• Cytotechnology 25%
• Cytology 25%
• Cell Biology 25%