Patterns of childhood solid tumor incidence in Northern Israel, 1973- 1990

Ariel Roguin, Shai Linn, Janet Dale, Myriam Weyl Ben Arush

Research output: Contribution to journalArticlepeer-review

Abstract

A retrospective analysis of 515 pediatric cancer cases diagnosed over 18 years, 1973-1990, showed an annual incidence of pediatric solid tumors in northern Israel of 77.1 per million, somewhat lower than previously reported. Lymphomas predominated over central nervous system (CNS) neoplasms, suggesting an Afro-Asian rather than a Western pattern. Jewish and non- Jewish children were at approximately equal risk (1:07: 1.0) for the nonleukemic cancers. However, there was a notably higher frequency in males than females (1:42: 1.0) and in Ashkenasi Jews as compared to either Sephardi Jews (1.25: 1.00) or non-Jews (1.23 : 1.0). Ethnic, age, and sex predispositions for particular types of malignancy were also noted. Non-Jews tended to have lymphomas or retinoblastomas and Sephardi Jews were predisposed to soft tissue sarcomas. Ashkenasi Jews tended to manifest CNS tumors, retinoblastoma, and osteosarcoma. Children under 5 years showed Burkitt's lymphoma and neuroblastoma, whereas the older group tended to have Hodgkin's lymphoma. Boys were more vulnerable to non-Hodgkin's lymphoma, medulloblastoma, neuroblastoma, and rhabdomyosarcoma, and girls were subject to higher incidences of bone, gonadal, germ cell and epithelial tumors, as weld as to astrocytoma. The implications for genetic or environmental contributions to several cancers are considered in conjunction with ethnic or gender predisposition to those cancers.

Original languageEnglish
Pages (from-to)525-537
Number of pages13
JournalPediatric Hematology and Oncology
Volume14
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Childhood cancer
  • Epidemiology
  • Incidence
  • Israel
  • Jews
  • Lymphoma
  • Pediatric

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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