Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats

M. Leshem; H. Frenk; R. C. Coghill; D. J. Mayer

doi:10.1016/0091-3057(91)90310-X

Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats

M. Leshem, H. Frenk, R. C. Coghill, D. J. Mayer

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Injections of high doses of etorphine (0.0625, 0.25, or 1.0 μmol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.

Original language	English
Pages (from-to)	475-478
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(91)90310-X
State	Published - Feb 1991

Bibliographical note

Funding Information:
The naloxone used was a generous gift from Endo Laboratones, Garden C~ty, NY Supported by PHS Grant DA 00576 to D J M

Keywords

Etorphine
Fentanyl
Opiate
Paralytic effects

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(91)90310-X

Cite this

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abstract = "Injections of high doses of etorphine (0.0625, 0.25, or 1.0 μmol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.",

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AU - Frenk, H.

AU - Coghill, R. C.

AU - Mayer, D. J.

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N2 - Injections of high doses of etorphine (0.0625, 0.25, or 1.0 μmol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.

AB - Injections of high doses of etorphine (0.0625, 0.25, or 1.0 μmol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.

KW - Etorphine

KW - Fentanyl

KW - Opiate

KW - Paralytic effects

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IS - 2

ER -

Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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