Injections of high doses of etorphine (0.0625, 0.25, or 1.0 μmol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.
Bibliographical noteFunding Information:
The naloxone used was a generous gift from Endo Laboratones, Garden C~ty, NY Supported by PHS Grant DA 00576 to D J M
- Paralytic effects
ASJC Scopus subject areas
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience