Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats

M. Leshem, H. Frenk, R. C. Coghill, D. J. Mayer

Research output: Contribution to journalArticlepeer-review

Abstract

Injections of high doses of etorphine (0.0625, 0.25, or 1.0 μmol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.

Original languageEnglish
Pages (from-to)475-478
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume38
Issue number2
DOIs
StatePublished - Feb 1991

Bibliographical note

Funding Information:
The naloxone used was a generous gift from Endo Laboratones, Garden C~ty, NY Supported by PHS Grant DA 00576 to D J M

Keywords

  • Etorphine
  • Fentanyl
  • Opiate
  • Paralytic effects

ASJC Scopus subject areas

  • Biological Psychiatry
  • Biochemistry
  • Behavioral Neuroscience
  • Clinical Biochemistry
  • Toxicology
  • Pharmacology

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