Panel construction for mapping in admixed populations via expected mutual information

Sivan Bercovici, Dan Geiger, Liran Shlush, Karl Skorecki, Alan Templeton

Research output: Contribution to journalArticlepeer-review

Abstract

Mapping by admixture linkage disequilibrium (MALD) is an economical and powerful approach for the identification of genomic regions harboring disease susceptibility genes in recently admixed populations. We develop an information-theory-based measure, called expected mutual information (EMI), which computes the impact of a set of markers on the ability to infer ancestry at each chromosomal location. We then present a simple and effective algorithm for the selection of panels that strives to maximize the EMI score. Finally, we demonstrate via well-established simulation tools that our panels provide more power and accuracy for inferring disease gene loci via the MALD method in comparison to previous methods.

Original languageEnglish
Pages (from-to)661-667
Number of pages7
JournalGenome Research
Volume18
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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