Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations

Yina Ma; Simone Shamay-Tsoory; Shihui Han; Caroline F. Zink

doi:10.1016/j.tics.2015.10.009

Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations

Yina Ma, Simone Shamay-Tsoory, Shihui Han, Caroline F. Zink

Department of Psychology

Research output: Contribution to journal › Review article › peer-review

Abstract

Adaptation to the social environment is critical for human survival. The neuropeptide oxytocin (OT), implicated in social cognition and emotions pivotal to sociality and well-being, is a promising pharmacological target for social and emotional dysfunction. We suggest here that the multifaceted role of OT in socio-affective processes improves the capability for social adaptation. We review OT effects on socio-affective processes, with a focus on OT-neuroimaging studies, to elucidate neuropsychological mechanisms through which OT promotes social adaptation. We also review OT-neuroimaging studies of individuals with social deficits and suggest that OT ameliorates impaired social adaptation by normalizing hyper- or hypo-brain activity. The social adaption model (SAM) provides an integrative understanding of discrepant OT effects and the modulations of OT action by personal milieu and context.

Original language	English
Pages (from-to)	133-145
Number of pages	13
Journal	Trends in Cognitive Sciences
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.tics.2015.10.009
State	Published - 1 Feb 2016

Bibliographical note

Funding Information:
This work was supported by startup funding from the State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning; Beijing Municipal Science & Technology Commission (Z151100003915122); and the National Natural Science Foundation of China (Projects 31421003, 31470986, 91332125).

Publisher Copyright:
© 2015 Elsevier Ltd.

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Experimental and Cognitive Psychology
Cognitive Neuroscience

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title = "Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations",

abstract = "Adaptation to the social environment is critical for human survival. The neuropeptide oxytocin (OT), implicated in social cognition and emotions pivotal to sociality and well-being, is a promising pharmacological target for social and emotional dysfunction. We suggest here that the multifaceted role of OT in socio-affective processes improves the capability for social adaptation. We review OT effects on socio-affective processes, with a focus on OT-neuroimaging studies, to elucidate neuropsychological mechanisms through which OT promotes social adaptation. We also review OT-neuroimaging studies of individuals with social deficits and suggest that OT ameliorates impaired social adaptation by normalizing hyper- or hypo-brain activity. The social adaption model (SAM) provides an integrative understanding of discrepant OT effects and the modulations of OT action by personal milieu and context.",

author = "Yina Ma and Simone Shamay-Tsoory and Shihui Han and Zink, {Caroline F.}",

note = "Funding Information: This work was supported by startup funding from the State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning; Beijing Municipal Science & Technology Commission (Z151100003915122); and the National Natural Science Foundation of China (Projects 31421003, 31470986, 91332125). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

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AB - Adaptation to the social environment is critical for human survival. The neuropeptide oxytocin (OT), implicated in social cognition and emotions pivotal to sociality and well-being, is a promising pharmacological target for social and emotional dysfunction. We suggest here that the multifaceted role of OT in socio-affective processes improves the capability for social adaptation. We review OT effects on socio-affective processes, with a focus on OT-neuroimaging studies, to elucidate neuropsychological mechanisms through which OT promotes social adaptation. We also review OT-neuroimaging studies of individuals with social deficits and suggest that OT ameliorates impaired social adaptation by normalizing hyper- or hypo-brain activity. The social adaption model (SAM) provides an integrative understanding of discrepant OT effects and the modulations of OT action by personal milieu and context.

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Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations

Abstract

Bibliographical note

ASJC Scopus subject areas

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