Use of the Academy of Nutrition and Dietetics (Academy) evidence-based nutrition practice guidelines has not been tested internationally. The International Diabetes Outcomes Study explored implementation of the Academy evidence-based nutrition practice guidelines in Turkey and Israel by registered dietitians. The mean hemoglobin A1c levels decreased from 7.6% to 9.1% at baseline to 6.2% to 7.4% for participants in Turkey and Israel, respectively. Patients at goal increased from baseline to 12 months for low-density lipoprotein cholesterol and triglyceride. Most subjective ratings for lifestyle behavior changes improved and were positively correlated with hemoglobin A1c change. Outcomes suggest that Academy evidence-based nutrition practice guidelines could be adopted internationally with resources for training, translation, and adaptations.