Otoacoustic emissions in the prediction of sudden sensorineural hearing loss outcome

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the role of otoacoustic emissions (OAEs) in the prediction of idiopathic sudden sensorineural hearing loss (ISSNHL) outcome.

Study Design: Open-label prospective study.

Setting: Tertiary referral medical center.

Patients: Fifteen ISSNHL patients (age: 57.6 ± 16.2 years) were prospectively followed 7 days, 14 days, and 3 months postpresentation and the commencement of treatment.

Intervention: Pure-tone audiometry, TEOAEs (Transient Evoked OAEs), and DPOAEs (Distortion Product OAEs) testing.

Main Outcome Measures: The pure-tone threshold averages of the three most affected frequencies, detectability, and the signalto-noise ratios (SNRs) values of the TEOAEs and DPOAEs were calculated. The main outcome measures were pure-tone hearing improvement, sensitivity, and specificity of the OAEs measures towards ISSNHL outcome.

Results: Patients having detectable TEOAEs on the first follow-up evaluation had average hearing improvement of 62 ± 41% whereas those with no response improved only by 11 ± 15% (P < 0.001). For the DPOAEs hearing improvement, results were 71 ± 37% and 10 ± 14%, respectively (P < 0.001). The sensitivity of recordable TEOAEs on the seventh day of follow-up towards the prediction of significant hearing improvement reached 71% and the specificity 100%. For the DPOAEs, the corresponding values were 83% and 100%. Univariate analysis showed significant contribution for the variance in hearing improvement by both TEOAEs and DPOAEs and their interaction (P values of 0.043, 0.005, and 0.009, respectively).

Conclusion: The results suggest potential role of TEOAEs and DPOAEs evaluation in the early stage of treatment in the prediction of ISSNHL outcome.

Original languageEnglish
Pages (from-to)1691-1697
Number of pages7
JournalOtology and Neurotology
Issue number10
StatePublished - 10 Dec 2014

Bibliographical note

Publisher Copyright:
© 2014, Otology & Neurotology, Inc.


  • Idiopathic sensorineural hearing loss
  • Otoacoustic emissions
  • Prediction

ASJC Scopus subject areas

  • Clinical Neurology
  • Sensory Systems
  • Otorhinolaryngology


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